Leung IKH - Search Results

1

Virtual screening and biophysical studies lead to HSP90 inhibitors.

Huang R, Ayine-Tora DM, Muhammad Rosdi MN, Li Y, Reynisson J, Leung IKH. Huang R, et al. Among authors: leung ikh. Bioorg Med Chem Lett. 2017 Jan 15;27(2):277-281. doi: 10.1016/j.bmcl.2016.11.059. Epub 2016 Nov 23. Bioorg Med Chem Lett. 2017. PMID: 27913182

2

Protein-Directed Dynamic Combinatorial Chemistry: A Guide to Protein Ligand and Inhibitor Discovery.

Huang R, Leung IK. Huang R, et al. Molecules. 2016 Jul 16;21(7):910. doi: 10.3390/molecules21070910. Molecules. 2016. PMID: 27438816 Free PMC article. Review.

3

Selective recognition of the di/trimethylammonium motif by an artificial carboxycalixarene receptor.

Hanauer T, Hopkinson RJ, Patel K, Li Y, Correddu D, Kawamura A, Sarojini V, Leung IK, Gruber T. Hanauer T, et al. Org Biomol Chem. 2017 Feb 1;15(5):1100-1105. doi: 10.1039/c6ob02616h. Org Biomol Chem. 2017. PMID: 28091667

4

Protein-ligand binding affinity determination by the waterLOGSY method: An optimised approach considering ligand rebinding.

Huang R, Bonnichon A, Claridge TD, Leung IK. Huang R, et al. Sci Rep. 2017 Mar 3;7:43727. doi: 10.1038/srep43727. Sci Rep. 2017. PMID: 28256624 Free PMC article.

5

Total synthesis of the proposed structure of talarolide A.

Zhang S, De Leon Rodriguez LM, Huang R, Leung IKH, Harris PWR, Brimble MA. Zhang S, et al. Among authors: leung ikh. Org Biomol Chem. 2018 Jul 25;16(29):5286-5293. doi: 10.1039/c8ob01230j. Org Biomol Chem. 2018. PMID: 29989642

6

MCR-1: a promising target for structure-based design of inhibitors to tackle polymyxin resistance.

Son SJ, Huang R, Squire CJ, Leung IKH. Son SJ, et al. Among authors: leung ikh. Drug Discov Today. 2019 Jan;24(1):206-216. doi: 10.1016/j.drudis.2018.07.004. Epub 2018 Jul 20. Drug Discov Today. 2019. PMID: 30036574 Review.

7

Development of NMR and thermal shift assays for the evaluation of Mycobacterium tuberculosis isocitrate lyase inhibitors.

Bhusal RP, Patel K, Kwai BXC, Swartjes A, Bashiri G, Reynisson J, Sperry J, Leung IKH. Bhusal RP, et al. Among authors: leung ikh. Medchemcomm. 2017 Oct 17;8(11):2155-2163. doi: 10.1039/c7md00456g. eCollection 2017 Nov 1. Medchemcomm. 2017. PMID: 30108733 Free PMC article.

8

A Novel Class of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Contains the Octahydro-2H-chromen-4-ol Scaffold.

Li-Zhulanov NS, Zakharenko AL, Chepanova AA, Patel J, Zafar A, Volcho KP, Salakhutdinov NF, Reynisson J, Leung IKH, Lavrik OI. Li-Zhulanov NS, et al. Among authors: leung ikh. Molecules. 2018 Sep 26;23(10):2468. doi: 10.3390/molecules23102468. Molecules. 2018. PMID: 30261631 Free PMC article.

9

Novel tyrosyl-DNA phosphodiesterase 1 inhibitors enhance the therapeutic impact of topoteсan on in vivo tumor models.

Zakharenko AL, Luzina OA, Sokolov DN, Kaledin VI, Nikolin VP, Popova NA, Patel J, Zakharova OD, Chepanova AA, Zafar A, Reynisson J, Leung E, Leung IKH, Volcho KP, Salakhutdinov NF, Lavrik OI. Zakharenko AL, et al. Among authors: leung e, leung ikh. Eur J Med Chem. 2019 Jan 1;161:581-593. doi: 10.1016/j.ejmech.2018.10.055. Epub 2018 Oct 28. Eur J Med Chem. 2019. PMID: 30396105

10

Novel Inhibitors of DNA Repair Enzyme TDP1 Combining Monoterpenoid and Adamantane Fragments.

Mozhaitsev ES, Zakharenko AL, Suslov EV, Korchagina DV, Zakharova OD, Vasil'eva IA, Chepanova AA, Black E, Patel J, Chand R, Reynisson J, Leung IKH, Volcho KP, Salakhutdinov NF, Lavrik OI. Mozhaitsev ES, et al. Among authors: leung ikh. Anticancer Agents Med Chem. 2019;19(4):463-472. doi: 10.2174/1871520619666181207094243. Anticancer Agents Med Chem. 2019. PMID: 30523770

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