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Inhibition of p38 signaling curtails the SARS-CoV-2 induced inflammatory response but retains the IFN-dependent antiviral defense of the lung epithelial barrier.
Faist A, Schloer S, Mecate-Zambrano A, Janowski J, Schreiber A, Boergeling Y, Conrad BCG, Kumar S, Toebben L, Schughart K, Baumgardt M, Kessler M, Hoenzke K, Hocke A, Trautmann M, Hartmann W, Kato H, Rescher U, Christersson A, Kuehn J, Mellmann A, Wolff T, Kuempers P, Rovas A, Wiewrodt R, Wiebe K, Barth P, Ludwig S, Brunotte L. Faist A, et al. Among authors: kuehn j. Antiviral Res. 2023 Jan;209:105475. doi: 10.1016/j.antiviral.2022.105475. Epub 2022 Nov 21. Antiviral Res. 2023. PMID: 36423831 Free PMC article.
Type IV-A3 CRISPR-Cas systems drive inter-plasmid conflicts by acquiring spacers in trans.
Benz F, Camara-Wilpert S, Russel J, Wandera KG, Čepaitė R, Ares-Arroyo M, Gomes-Filho JV, Englert F, Kuehn JA, Gloor S, Mestre MR, Cuénod A, Aguilà-Sans M, Maccario L, Egli A, Randau L, Pausch P, Rocha EPC, Beisel CL, Madsen JS, Bikard D, Hall AR, Sørensen SJ, Pinilla-Redondo R. Benz F, et al. Among authors: kuehn ja. Cell Host Microbe. 2024 May 7:S1931-3128(24)00135-5. doi: 10.1016/j.chom.2024.04.016. Online ahead of print. Cell Host Microbe. 2024. PMID: 38754416
Surrogate Virus Neutralisation Test Based on Nanoluciferase-Tagged Antigens to Quantify Inhibitory Antibodies against SARS-CoV-2 and Characterise Omicron-Specific Reactivity in a Vaccination Cohort.
Schoefbaenker M, Neddermeyer R, Guenther T, Mueller MM, Romberg ML, Classen N, Hennies MT, Hrincius ER, Ludwig S, Kuehn JE, Lorentzen EU. Schoefbaenker M, et al. Among authors: kuehn je. Vaccines (Basel). 2023 Dec 8;11(12):1832. doi: 10.3390/vaccines11121832. Vaccines (Basel). 2023. PMID: 38140236 Free PMC article.
Improved early outcome prediction by MRI-based 3D tumor volume assessment in patients with CNS lymphomas.
Lauer EM, Riegler E, Mutter JA, Alig SK, Bleul S, Kuehn J, Ranganathan L, Klingler C, Demerath T, Würtemberger U, Rau A, Weiß J, Eisenblaetter M, Bamberg F, Prinz M, Finke J, Duyster J, Illerhaus G, Diehn M, Alizadeh AA, Schorb E, Reinacher PC, Scherer F. Lauer EM, et al. Among authors: kuehn j. Neuro Oncol. 2024 Feb 2;26(2):374-386. doi: 10.1093/neuonc/noad177. Neuro Oncol. 2024. PMID: 37713267
COVID-19 rapid molecular point-of-care testing is effective and cost-beneficial for the acute care of trauma patients.
Stolberg-Stolberg J, Jacob E, Kuehn J, Hennies M, Hafezi W, Freistuehler M, Koeppe J, Friedrich AW, Katthagen JC, Raschke MJ. Stolberg-Stolberg J, et al. Among authors: kuehn j. Eur J Trauma Emerg Surg. 2023 Feb;49(1):487-493. doi: 10.1007/s00068-022-02091-x. Epub 2022 Sep 6. Eur J Trauma Emerg Surg. 2023. PMID: 36066585 Free PMC article.
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