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The downregulation of GFI1 by the EZH2-NDY1/KDM2B-JARID2 axis and by human cytomegalovirus (HCMV) associated factors allows the activation of the HCMV major IE promoter and the transition to productive infection.
Sourvinos G, Morou A, Sanidas I, Codruta I, Ezell SA, Doxaki C, Kampranis SC, Kottakis F, Tsichlis PN. Sourvinos G, et al. Among authors: kottakis f. PLoS Pathog. 2014 May 15;10(5):e1004136. doi: 10.1371/journal.ppat.1004136. eCollection 2014 May. PLoS Pathog. 2014. PMID: 24830456 Free PMC article.
Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation.
Nicolay BN, Danielian PS, Kottakis F, Lapek JD Jr, Sanidas I, Miles WO, Dehnad M, Tschöp K, Gierut JJ, Manning AL, Morris R, Haigis K, Bardeesy N, Lees JA, Haas W, Dyson NJ. Nicolay BN, et al. Among authors: kottakis f. Genes Dev. 2015 Sep 1;29(17):1875-89. doi: 10.1101/gad.264127.115. Epub 2015 Aug 27. Genes Dev. 2015. PMID: 26314710 Free PMC article.
NRF2: Translating the Redox Code.
Tummala KS, Kottakis F, Bardeesy N. Tummala KS, et al. Among authors: kottakis f. Trends Mol Med. 2016 Oct;22(10):829-831. doi: 10.1016/j.molmed.2016.08.002. Epub 2016 Aug 20. Trends Mol Med. 2016. PMID: 27555347 Free PMC article.
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