NRF2: Translating the Redox Code

Trends Mol Med. 2016 Oct;22(10):829-831. doi: 10.1016/j.molmed.2016.08.002. Epub 2016 Aug 20.

Abstract

Cancer requires mechanisms to mitigate reactive oxygen species (ROS) generated during rapid growth, such as induction of the antioxidant transcription factor, Nrf2. However, the targets of ROS-mediated cytotoxicity are unclear. Recent studies in pancreatic cancer show that redox control by Nrf2 prevents cysteine oxidation of the mRNA translational machinery, thereby supporting efficient protein synthesis.

MeSH terms

  • Animals
  • Cysteine / metabolism
  • Humans
  • NF-E2-Related Factor 2 / metabolism*
  • Oxidation-Reduction
  • Oxidative Stress
  • Pancreas / metabolism
  • Pancreatic Neoplasms / metabolism*
  • Protein Biosynthesis*
  • Reactive Oxygen Species / metabolism*

Substances

  • NF-E2-Related Factor 2
  • NFE2L2 protein, human
  • Reactive Oxygen Species
  • Cysteine