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Potent Kv1.3 inhibitors from correolide-modification of the C18 position.
Bao J, Miao S, Kayser F, Kotliar AJ, Baker RK, Doss GA, Felix JP, Bugianesi RM, Slaughter RS, Kaczorowski GJ, Garcia ML, Ha SN, Castonguay L, Koo GC, Shah K, Springer MS, Staruch MJ, Parsons WH, Rupprecht KM. Bao J, et al. Among authors: kotliar aj. Bioorg Med Chem Lett. 2005 Jan 17;15(2):447-51. doi: 10.1016/j.bmcl.2004.10.058. Bioorg Med Chem Lett. 2005. PMID: 15603971
Benzamide derivatives as blockers of Kv1.3 ion channel.
Miao S, Bao J, Garcia ML, Goulet JL, Hong XJ, Kaczorowski GJ, Kayser F, Koo GC, Kotliar A, Schmalhofer WA, Shah K, Sinclair PJ, Slaughter RS, Springer MS, Staruch MJ, Tsou NN, Wong F, Parsons WH, Rupprecht KM. Miao S, et al. Among authors: kotliar a. Bioorg Med Chem Lett. 2003 Mar 24;13(6):1161-4. doi: 10.1016/s0960-894x(03)00014-3. Bioorg Med Chem Lett. 2003. PMID: 12643934
Novel fragmentation reaction of correolide.
Bao J, Baker RK, Doss GA, Kayser F, Kotliar A, Miao S, Parsons WH, Rupprecht KM. Bao J, et al. Among authors: kotliar a. Org Lett. 2002 May 30;4(11):1871-3. doi: 10.1021/ol020053g. Org Lett. 2002. PMID: 12027635
A potent, orally bioavailable benzazepinone growth hormone secretagogue.
DeVita RJ, Bochis R, Frontier AJ, Kotliar A, Fisher MH, Schoen WR, Wyvratt MJ, Cheng K, Chan WW, Butler B, Jacks TM, Hickey GJ, Schleim KD, Leung K, Chen Z, Chiu SL, Feeney WP, Cunningham PK, Smith RG. DeVita RJ, et al. Among authors: kotliar a. J Med Chem. 1998 May 7;41(10):1716-28. doi: 10.1021/jm970816j. J Med Chem. 1998. PMID: 9572898
30 results