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Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs.
Steinebach C, Bricelj A, Murgai A, Sosič I, Bischof L, Ng YLD, Heim C, Maiwald S, Proj M, Voget R, Feller F, Košmrlj J, Sapozhnikova V, Schmidt A, Zuleeg MR, Lemnitzer P, Mertins P, Hansen FK, Gütschow M, Krönke J, Hartmann MD. Steinebach C, et al. Among authors: kosmrlj j. J Med Chem. 2023 Nov 9;66(21):14513-14543. doi: 10.1021/acs.jmedchem.3c00851. Epub 2023 Oct 30. J Med Chem. 2023. PMID: 37902300 Free PMC article.
Biological evaluation of diazene derivatives as anti-tubercular compounds.
Cappoen D, Majce V, Uythethofken C, Urankar D, Mathys V, Kočevar M, Verschaeve L, Polanc S, Huygen K, Košmrlj J. Cappoen D, et al. Among authors: kosmrlj j. Eur J Med Chem. 2014 Mar 3;74:85-94. doi: 10.1016/j.ejmech.2013.12.057. Epub 2014 Jan 8. Eur J Med Chem. 2014. PMID: 24448419
Anti-mycobacterial activity of 1,3-diaryltriazenes.
Cappoen D, Vajs J, Uythethofken C, Virag A, Mathys V, Kočevar M, Verschaeve L, Gazvoda M, Polanc S, Huygen K, Košmrlj J. Cappoen D, et al. Among authors: kosmrlj j. Eur J Med Chem. 2014 Apr 22;77:193-203. doi: 10.1016/j.ejmech.2014.02.065. Epub 2014 Mar 1. Eur J Med Chem. 2014. PMID: 24631899
Design, synthesis and antitubercular potency of 4-hydroxyquinolin-2(1H)-ones.
de Macedo MB, Kimmel R, Urankar D, Gazvoda M, Peixoto A, Cools F, Torfs E, Verschaeve L, Lima ES, Lyčka A, Milićević D, Klásek A, Cos P, Kafka S, Košmrlj J, Cappoen D. de Macedo MB, et al. Among authors: kosmrlj j. Eur J Med Chem. 2017 Sep 29;138:491-500. doi: 10.1016/j.ejmech.2017.06.061. Epub 2017 Jun 29. Eur J Med Chem. 2017. PMID: 28689097
Arylation of Click Triazoles with Diaryliodonium Salts.
Virant M, Košmrlj J. Virant M, et al. Among authors: kosmrlj j. J Org Chem. 2019 Nov 1;84(21):14030-14044. doi: 10.1021/acs.joc.9b02197. Epub 2019 Oct 10. J Org Chem. 2019. PMID: 31553192 Free article.
71 results