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A universal deep-learning model for zinc finger design enables transcription factor reprogramming.
Ichikawa DM, Abdin O, Alerasool N, Kogenaru M, Mueller AL, Wen H, Giganti DO, Goldberg GW, Adams S, Spencer JM, Razavi R, Nim S, Zheng H, Gionco C, Clark FT, Strokach A, Hughes TR, Lionnet T, Taipale M, Kim PM, Noyes MB. Ichikawa DM, et al. Among authors: kim pm. Nat Biotechnol. 2023 Aug;41(8):1117-1129. doi: 10.1038/s41587-022-01624-4. Epub 2023 Jan 26. Nat Biotechnol. 2023. PMID: 36702896 Free PMC article.
Disrupting the α-synuclein-ESCRT interaction with a peptide inhibitor mitigates neurodegeneration in preclinical models of Parkinson's disease.
Nim S, O'Hara DM, Corbi-Verge C, Perez-Riba A, Fujisawa K, Kapadia M, Chau H, Albanese F, Pawar G, De Snoo ML, Ngana SG, Kim J, El-Agnaf OMA, Rennella E, Kay LE, Kalia SK, Kalia LV, Kim PM. Nim S, et al. Among authors: kim j, kim pm. Nat Commun. 2023 Apr 19;14(1):2150. doi: 10.1038/s41467-023-37464-2. Nat Commun. 2023. PMID: 37076542 Free PMC article.
Rapid protein model refinement by deep learning.
Abdin O, Kim PM. Abdin O, et al. Among authors: kim pm. Nat Comput Sci. 2021 Jul;1(7):456-457. doi: 10.1038/s43588-021-00104-0. Nat Comput Sci. 2021. PMID: 38217116 No abstract available.
149 results