Computational structural analysis of protein interactions and networks

Proteomics. 2012 May;12(10):1697-705. doi: 10.1002/pmic.201100597.

Abstract

Protein interactions have been at the focus of computational biology in recent years. In particular, interest has come from two different communities--structural and systems biology. Here, we will discuss key systems and structural biology methods that have been used for analysis and prediction of protein-protein interactions and the insight these approaches have provided on the nature and organization of protein-protein interactions inside cells.

Publication types

  • Review

MeSH terms

  • Animals
  • Artificial Intelligence
  • Computational Biology / methods*
  • Humans
  • Mice
  • Models, Molecular
  • Protein Conformation
  • Protein Interaction Mapping / methods*
  • Protein Interaction Maps
  • Proteins / chemistry*
  • Proteins / metabolism*

Substances

  • Proteins