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A novel role for CD26/dipeptidyl peptidase IV as a therapeutic target.
Ohnuma K, Hatano R, Komiya E, Otsuka H, Itoh T, Iwao N, Kaneko Y, Yamada T, Dang NH, Morimoto C. Ohnuma K, et al. Among authors: kaneko y. Front Biosci (Landmark Ed). 2018 Jun 1;23(9):1754-1779. doi: 10.2741/4671. Front Biosci (Landmark Ed). 2018. PMID: 29772527 Free article. Review.
First-in-human phase 1 of YS110, a monoclonal antibody directed against CD26 in advanced CD26-expressing cancers.
Angevin E, Isambert N, Trillet-Lenoir V, You B, Alexandre J, Zalcman G, Vielh P, Farace F, Valleix F, Podoll T, Kuramochi Y, Miyashita I, Hosono O, Dang NH, Ohnuma K, Yamada T, Kaneko Y, Morimoto C. Angevin E, et al. Among authors: kaneko y. Br J Cancer. 2017 Apr 25;116(9):1126-1134. doi: 10.1038/bjc.2017.62. Epub 2017 Mar 14. Br J Cancer. 2017. PMID: 28291776 Free PMC article. Clinical Trial.
Serum soluble CD26/DPP4 titer variation is a potential prognostic biomarker in cancer therapy with a humanized anti-CD26 antibody.
Kaneko Y, Hatano R, Hirota N, Isambert N, Trillet-Lenoir V, You B, Alexandre J, Zalcman G, Valleix F, Podoll T, Umezawa Y, Takao S, Iwata S, Hosono O, Taguchi T, Yamada T, Dang NH, Ohnuma K, Angevin E, Morimoto C. Kaneko Y, et al. Biomark Res. 2021 Mar 23;9(1):21. doi: 10.1186/s40364-021-00273-0. Biomark Res. 2021. PMID: 33757558 Free PMC article.
IL-26 mediates epidermal growth factor receptor-tyrosine kinase inhibitor resistance through endoplasmic reticulum stress signaling pathway in triple-negative breast cancer cells.
Itoh T, Hatano R, Horimoto Y, Yamada T, Song D, Otsuka H, Shirakawa Y, Mastuoka S, Iwao N, Aune TM, Dang NH, Kaneko Y, Okumura K, Morimoto C, Ohnuma K. Itoh T, et al. Among authors: kaneko y. Cell Death Dis. 2021 May 21;12(6):520. doi: 10.1038/s41419-021-03787-5. Cell Death Dis. 2021. PMID: 34021125 Free PMC article.
Phase I study of YS110, a recombinant humanized monoclonal antibody to CD26, in Japanese patients with advanced malignant pleural mesothelioma.
Takeda M, Ohe Y, Horinouchi H, Hida T, Shimizu J, Seto T, Nosaki K, Kishimoto T, Miyashita I, Yamada M, Kaneko Y, Morimoto C, Nakagawa K. Takeda M, et al. Among authors: kaneko y. Lung Cancer. 2019 Nov;137:64-70. doi: 10.1016/j.lungcan.2019.09.010. Epub 2019 Sep 16. Lung Cancer. 2019. PMID: 31557561 Free article. Clinical Trial.
Phase 2 Study of YS110, a Recombinant Humanized Anti-CD26 Monoclonal Antibody, in Japanese Patients With Advanced Malignant Pleural Mesothelioma.
Nakagawa K, Kijima T, Okada M, Morise M, Kato M, Hirano K, Fujimoto N, Takenoyama M, Yokouchi H, Ohe Y, Hida T, Aoe K, Kishimoto T, Hirokawa M, Matsuki H, Kaneko Y, Yamada T, Morimoto C, Takeda M. Nakagawa K, et al. Among authors: kaneko y. JTO Clin Res Rep. 2021 Apr 29;2(6):100178. doi: 10.1016/j.jtocrr.2021.100178. eCollection 2021 Jun. JTO Clin Res Rep. 2021. PMID: 34590026 Free PMC article.
3,377 results