Junker A - Search Results

1

Development of Bicyclo[3.1.0]hexane-Based A₃ Receptor Ligands: Closing the Gaps in the Structure-Affinity Relationships.

Lemmerhirt JP, Isaak A, Liu R, Kock M, Daniliuc CG, Jacobson KA, Heitman LH, Junker A. Lemmerhirt JP, et al. Among authors: junker a. Molecules. 2022 Mar 31;27(7):2283. doi: 10.3390/molecules27072283. Molecules. 2022. PMID: 35408685 Free PMC article.

2

Synthesis, binding affinity and structure-activity relationships of novel, selective and dual targeting CCR2 and CCR5 receptor antagonists.

Junker A, Kokornaczyk AK, Zweemer AJ, Frehland B, Schepmann D, Yamaguchi J, Itami K, Faust A, Hermann S, Wagner S, Schäfers M, Koch M, Weiss C, Heitman LH, Kopka K, Wünsch B. Junker A, et al. Org Biomol Chem. 2015 Feb 28;13(8):2407-22. doi: 10.1039/c4ob02397h. Org Biomol Chem. 2015. PMID: 25566983

3

Synthesis and biological evaluation of spirocyclic antagonists of CCR2 (chemokine CC receptor subtype 2).

Strunz AK, Zweemer AJ, Weiss C, Schepmann D, Junker A, Heitman LH, Koch M, Wünsch B. Strunz AK, et al. Among authors: junker a. Bioorg Med Chem. 2015 Jul 15;23(14):4034-49. doi: 10.1016/j.bmc.2015.02.019. Epub 2015 Feb 18. Bioorg Med Chem. 2015. PMID: 25766632

4

Structure-Based Design of 3-(4-Aryl-1H-1,2,3-triazol-1-yl)-Biphenyl Derivatives as P2Y14 Receptor Antagonists.

Junker A, Balasubramanian R, Ciancetta A, Uliassi E, Kiselev E, Martiriggiano C, Trujillo K, Mtchedlidze G, Birdwell L, Brown KA, Harden TK, Jacobson KA. Junker A, et al. J Med Chem. 2016 Jul 14;59(13):6149-68. doi: 10.1021/acs.jmedchem.6b00044. Epub 2016 Jun 22. J Med Chem. 2016. PMID: 27331270 Free PMC article.

5

Synthesis and biological evaluation of chemokine receptor ligands with 2-benzazepine scaffold.

Thum S, Kokornaczyk AK, Seki T, De Maria M, Ortiz Zacarias NV, de Vries H, Weiss C, Koch M, Schepmann D, Kitamura M, Tschammer N, Heitman LH, Junker A, Wünsch B. Thum S, et al. Among authors: junker a. Eur J Med Chem. 2017 Jul 28;135:401-413. doi: 10.1016/j.ejmech.2017.04.046. Epub 2017 Apr 22. Eur J Med Chem. 2017. PMID: 28463783

6

Structure-Activity Relationship of Purine and Pyrimidine Nucleotides as Ecto-5'-Nucleotidase (CD73) Inhibitors.

Junker A, Renn C, Dobelmann C, Namasivayam V, Jain S, Losenkova K, Irjala H, Duca S, Balasubramanian R, Chakraborty S, Börgel F, Zimmermann H, Yegutkin GG, Müller CE, Jacobson KA. Junker A, et al. J Med Chem. 2019 Apr 11;62(7):3677-3695. doi: 10.1021/acs.jmedchem.9b00164. Epub 2019 Mar 21. J Med Chem. 2019. PMID: 30895781 Free PMC article.

7

Development of the First Potential Nonpeptidic Positron Emission Tomography Tracer for the Imaging of CCR2 Receptors.

Wagner S, de Moura Gatti F, Silva DG, Ortiz Zacarias NV, Zweemer AJM, Hermann S, De Maria M, Koch M, Weiss C, Schepmann D, Heitman LH, Tschammer N, Kopka K, Junker A. Wagner S, et al. Among authors: junker a. ChemMedChem. 2021 Feb 17;16(4):640-645. doi: 10.1002/cmdc.202000728. Epub 2020 Nov 23. ChemMedChem. 2021. PMID: 33205603 Free PMC article.

8

Structure-activity relationships of pyrimidine nucleotides containing a 5'-α,β-methylene diphosphonate at the P2Y₆ receptor.

Oliva P, Scortichini M, Dobelmann C, Jain S, Gopinatth V, Toti KS, Phung NB, Junker A, Jacobson KA. Oliva P, et al. Among authors: junker a. Bioorg Med Chem Lett. 2021 Aug 1;45:128137. doi: 10.1016/j.bmcl.2021.128137. Epub 2021 May 26. Bioorg Med Chem Lett. 2021. PMID: 34048882 Free PMC article.

9

Piperazine squaric acid diamides, a novel class of allosteric P2X7 receptor antagonists.

Patberg M, Isaak A, Füsser F, Ortiz Zacarías NV, Vinnenberg L, Schulte J, Michetti L, Grey L, van der Horst C, Hundehege P, Koch O, Heitman LH, Budde T, Junker A. Patberg M, et al. Among authors: junker a. Eur J Med Chem. 2021 Dec 15;226:113838. doi: 10.1016/j.ejmech.2021.113838. Epub 2021 Sep 16. Eur J Med Chem. 2021. PMID: 34571173

10

Structure-Activity Relationship of 3-Methylcytidine-5'-α,β-methylenediphosphates as CD73 Inhibitors.

Scortichini M, Idris RM, Moschütz S, Keim A, Salmaso V, Dobelmann C, Oliva P, Losenkova K, Irjala H, Vaittinen S, Sandholm J, Yegutkin GG, Sträter N, Junker A, Müller CE, Jacobson KA. Scortichini M, et al. Among authors: junker a. J Med Chem. 2022 Feb 10;65(3):2409-2433. doi: 10.1021/acs.jmedchem.1c01852. Epub 2022 Jan 26. J Med Chem. 2022. PMID: 35080883 Free PMC article.

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