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Inhibition of nonalcoholic fatty liver disease in mice by selective inhibition of mTORC1.
Gosis BS, Wada S, Thorsheim C, Li K, Jung S, Rhoades JH, Yang Y, Brandimarto J, Li L, Uehara K, Jang C, Lanza M, Sanford NB, Bornstein MR, Jeong S, Titchenell PM, Biddinger SB, Arany Z. Gosis BS, et al. Among authors: jang c. Science. 2022 Apr 15;376(6590):eabf8271. doi: 10.1126/science.abf8271. Epub 2022 Apr 15. Science. 2022. PMID: 35420934 Free PMC article.
Metabolism: Sweet enticements to move.
Jang C, Arany Z. Jang C, et al. Nature. 2013 Aug 22;500(7463):409-11. doi: 10.1038/nature12549. Epub 2013 Aug 14. Nature. 2013. PMID: 23945589 Free PMC article.
A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance.
Jang C, Oh SF, Wada S, Rowe GC, Liu L, Chan MC, Rhee J, Hoshino A, Kim B, Ibrahim A, Baca LG, Kim E, Ghosh CC, Parikh SM, Jiang A, Chu Q, Forman DE, Lecker SH, Krishnaiah S, Rabinowitz JD, Weljie AM, Baur JA, Kasper DL, Arany Z. Jang C, et al. Nat Med. 2016 Apr;22(4):421-6. doi: 10.1038/nm.4057. Epub 2016 Mar 7. Nat Med. 2016. PMID: 26950361 Free PMC article.
PDK4 Inhibits Cardiac Pyruvate Oxidation in Late Pregnancy.
Liu LX, Rowe GC, Yang S, Li J, Damilano F, Chan MC, Lu W, Jang C, Wada S, Morley M, Hesse M, Fleischmann BK, Rabinowitz JD, Das S, Rosenzweig A, Arany Z. Liu LX, et al. Among authors: jang c. Circ Res. 2017 Dec 8;121(12):1370-1378. doi: 10.1161/CIRCRESAHA.117.311456. Epub 2017 Sep 19. Circ Res. 2017. PMID: 28928113 Free PMC article.
Endothelial pyruvate kinase M2 maintains vascular integrity.
Kim B, Jang C, Dharaneeswaran H, Li J, Bhide M, Yang S, Li K, Arany Z. Kim B, et al. Among authors: jang c. J Clin Invest. 2018 Oct 1;128(10):4543-4556. doi: 10.1172/JCI120912. Epub 2018 Sep 17. J Clin Invest. 2018. PMID: 30222136 Free PMC article.
1,231 results