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Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells.
Shmuel-Galia L, Humphries F, Lei X, Ceglia S, Wilson R, Jiang Z, Ketelut-Carneiro N, Foley SE, Pechhold S, Houghton J, Muneeruddin K, Shaffer SA, McCormick BA, Reboldi A, Ward D, Marshak-Rothstein A, Fitzgerald KA. Shmuel-Galia L, et al. Among authors: humphries f. Immunity. 2021 Jun 8;54(6):1137-1153.e8. doi: 10.1016/j.immuni.2021.05.008. Epub 2021 May 28. Immunity. 2021. PMID: 34051146 Free PMC article.
Gasdermin D restricts anti-tumor immunity during PD-L1 checkpoint blockade.
Jiang Y, Yang Y, Hu Y, Yang R, Huang J, Liu Y, Wu Y, Li S, Ma C, Humphries F, Wang B, Wang X, Hu Z, Yang S. Jiang Y, et al. Among authors: humphries f. Cell Rep. 2022 Oct 25;41(4):111553. doi: 10.1016/j.celrep.2022.111553. Cell Rep. 2022. PMID: 36288704 Free article.
Assembling the Inflammasome, Piece by Piece.
Humphries F, Fitzgerald KA. Humphries F, et al. J Immunol. 2019 Sep 1;203(5):1093-1094. doi: 10.4049/jimmunol.1900764. J Immunol. 2019. PMID: 31427397 No abstract available.
Succination inactivates gasdermin D and blocks pyroptosis.
Humphries F, Shmuel-Galia L, Ketelut-Carneiro N, Li S, Wang B, Nemmara VV, Wilson R, Jiang Z, Khalighinejad F, Muneeruddin K, Shaffer SA, Dutta R, Ionete C, Pesiridis S, Yang S, Thompson PR, Fitzgerald KA. Humphries F, et al. Science. 2020 Sep 25;369(6511):1633-1637. doi: 10.1126/science.abb9818. Epub 2020 Aug 20. Science. 2020. PMID: 32820063 Free PMC article.
Loosening the grip on nuclear cGAS.
Humphries F, Fitzgerald KA. Humphries F, et al. Nat Genet. 2020 Dec;52(12):1269-1270. doi: 10.1038/s41588-020-00746-2. Nat Genet. 2020. PMID: 33230301 No abstract available.
The lncRNA HOXA11os regulates mitochondrial function in myeloid cells to maintain intestinal homeostasis.
Shmuel-Galia L, Humphries F, Vierbuchen T, Jiang Z, Santos N, Johnson J, Shklyar B, Joannas L, Mustone N, Sherman S, Ward D, Houghton J, Baer CE, O'Hara A, Henao-Mejia J, Hoebe K, Fitzgerald KA. Shmuel-Galia L, et al. Among authors: humphries f. Cell Metab. 2023 Aug 8;35(8):1441-1456.e9. doi: 10.1016/j.cmet.2023.06.019. Epub 2023 Jul 25. Cell Metab. 2023. PMID: 37494932
44 results