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Macrolones Are a Novel Class of Macrolide Antibiotics Active against Key Resistant Respiratory Pathogens In Vitro and In Vivo.
Čipčić Paljetak H, Verbanac D, Padovan J, Dominis-Kramarić M, Kelnerić Ž, Perić M, Banjanac M, Ergović G, Simon N, Broskey J, Holmes DJ, Eraković Haber V. Čipčić Paljetak H, et al. Among authors: holmes dj. Antimicrob Agents Chemother. 2016 Aug 22;60(9):5337-48. doi: 10.1128/AAC.00524-16. Print 2016 Sep. Antimicrob Agents Chemother. 2016. PMID: 27353268 Free PMC article.
4''-O-(omega-Quinolylamino-alkylamino)propionyl derivatives of selected macrolides with the activity against the key erythromycin resistant respiratory pathogens.
Fajdetić A, Cipcić Paljetak H, Lazarevski G, Hutinec A, Alihodzić S, Derek M, Stimac V, Andreotti D, Sunjić V, Berge JM, Mutak S, Dumić M, Lociuro S, Holmes DJ, Marsić N, Eraković Haber V, Spaventi R. Fajdetić A, et al. Among authors: holmes dj. Bioorg Med Chem. 2010 Sep 1;18(17):6559-68. doi: 10.1016/j.bmc.2010.06.049. Epub 2010 Jun 22. Bioorg Med Chem. 2010. PMID: 20634078
Synthesis and properties of macrolones characterized by two ether bonds in the linker.
Jakopović IP, Kragol G, Forrest AK, Frydrych CS, Stimac V, Kapić S, Skugor MM, Ilijas M, Paljetak HC, Jelić D, Holmes DJ, Hickey DM, Verbanac D, Eraković Haber V, Alihodzić S. Jakopović IP, et al. Among authors: holmes dj. Bioorg Med Chem. 2010 Sep 1;18(17):6578-88. doi: 10.1016/j.bmc.2010.07.007. Epub 2010 Jul 14. Bioorg Med Chem. 2010. PMID: 20688524
Synthesis and biological activity of 4''-O-acyl derivatives of 14- and 15-membered macrolides linked to omega-quinolone-carboxylic unit.
Skugor MM, Stimac V, Palej I, Lugarić D, Paljetak HC, Filić D, Modrić M, Dilović I, Gembarovski D, Mutak S, Eraković Haber V, Holmes DJ, Ivezić-Schoenfeld Z, Alihodzić S. Skugor MM, et al. Among authors: holmes dj. Bioorg Med Chem. 2010 Sep 1;18(17):6547-58. doi: 10.1016/j.bmc.2010.06.050. Epub 2010 Jun 22. Bioorg Med Chem. 2010. PMID: 20621489
Frequency of Spontaneous Resistance to Peptide Deformylase Inhibitor GSK1322322 in Haemophilus influenzae, Staphylococcus aureus, Streptococcus pyogenes, and Streptococcus pneumoniae.
Min S, Ingraham K, Huang J, McCloskey L, Rilling S, Windau A, Pizzollo J, Butler D, Aubart K, Miller LA, Zalacain M, Holmes DJ, O'Dwyer K. Min S, et al. Among authors: holmes dj. Antimicrob Agents Chemother. 2015 Aug;59(8):4644-52. doi: 10.1128/AAC.00484-15. Epub 2015 May 26. Antimicrob Agents Chemother. 2015. PMID: 26014938 Free PMC article.
Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment of complicated urinary tract infections.
O'Dwyer K, Spivak AT, Ingraham K, Min S, Holmes DJ, Jakielaszek C, Rittenhouse S, Kwan AL, Livi GP, Sathe G, Thomas E, Van Horn S, Miller LA, Twynholm M, Tomayko J, Dalessandro M, Caltabiano M, Scangarella-Oman NE, Brown JR. O'Dwyer K, et al. Among authors: holmes dj. Antimicrob Agents Chemother. 2015 Jan;59(1):289-98. doi: 10.1128/AAC.03774-14. Epub 2014 Oct 27. Antimicrob Agents Chemother. 2015. PMID: 25348524 Free PMC article. Clinical Trial.
87 results