Abstract
The synthesis and antimicrobial activity of a new class of macrolide antibiotics which consist of a macrolide scaffold and a quinolone unit covalently connected by an appropriate linker are described. Optimization of several synthetic steps and structural properties of lead compound 26 are discussed. Promising antibacterial properties of this compound and some of its analogues are reported.
Copyright 2010 Elsevier Ltd. All rights reserved.
MeSH terms
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology
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Drug Resistance, Microbial
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Humans
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Macrolides / chemical synthesis*
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Macrolides / chemistry
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Macrolides / pharmacology*
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Molecular Conformation
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Molecular Structure
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Quinolones / chemical synthesis*
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Quinolones / chemistry
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Quinolones / pharmacology*
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Structure-Activity Relationship
Substances
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Anti-Bacterial Agents
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Macrolides
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Quinolones