Heitman LH - Search Results

1

Development of Bicyclo[3.1.0]hexane-Based A₃ Receptor Ligands: Closing the Gaps in the Structure-Affinity Relationships.

Lemmerhirt JP, Isaak A, Liu R, Kock M, Daniliuc CG, Jacobson KA, Heitman LH, Junker A. Lemmerhirt JP, et al. Among authors: heitman lh. Molecules. 2022 Mar 31;27(7):2283. doi: 10.3390/molecules27072283. Molecules. 2022. PMID: 35408685 Free PMC article.

2

A series of 2,4-disubstituted quinolines as a new class of allosteric enhancers of the adenosine A3 receptor.

Heitman LH, Göblyös A, Zweemer AM, Bakker R, Mulder-Krieger T, van Veldhoven JP, de Vries H, Brussee J, Ijzerman AP. Heitman LH, et al. J Med Chem. 2009 Feb 26;52(4):926-31. doi: 10.1021/jm8014052. J Med Chem. 2009. PMID: 19161279

3

Functional efficacy of adenosine A₂A receptor agonists is positively correlated to their receptor residence time.

Guo D, Mulder-Krieger T, IJzerman AP, Heitman LH. Guo D, et al. Among authors: heitman lh. Br J Pharmacol. 2012 Jul;166(6):1846-59. doi: 10.1111/j.1476-5381.2012.01897.x. Br J Pharmacol. 2012. PMID: 22324512 Free PMC article.

4

Synthesis, binding affinity and structure-activity relationships of novel, selective and dual targeting CCR2 and CCR5 receptor antagonists.

Junker A, Kokornaczyk AK, Zweemer AJ, Frehland B, Schepmann D, Yamaguchi J, Itami K, Faust A, Hermann S, Wagner S, Schäfers M, Koch M, Weiss C, Heitman LH, Kopka K, Wünsch B. Junker A, et al. Among authors: heitman lh. Org Biomol Chem. 2015 Feb 28;13(8):2407-22. doi: 10.1039/c4ob02397h. Org Biomol Chem. 2015. PMID: 25566983

5

Synthesis and biological evaluation of spirocyclic antagonists of CCR2 (chemokine CC receptor subtype 2).

Strunz AK, Zweemer AJ, Weiss C, Schepmann D, Junker A, Heitman LH, Koch M, Wünsch B. Strunz AK, et al. Among authors: heitman lh. Bioorg Med Chem. 2015 Jul 15;23(14):4034-49. doi: 10.1016/j.bmc.2015.02.019. Epub 2015 Feb 18. Bioorg Med Chem. 2015. PMID: 25766632

6

Structure-Affinity Relationships (SARs) and Structure-Kinetics Relationships (SKRs) of Kv11.1 Blockers.

Yu Z, van Veldhoven JP, Louvel J, 't Hart IM, Rook MB, van der Heyden MA, Heitman LH, IJzerman AP. Yu Z, et al. Among authors: heitman lh. J Med Chem. 2015 Aug 13;58(15):5916-29. doi: 10.1021/acs.jmedchem.5b00518. Epub 2015 Jul 17. J Med Chem. 2015. PMID: 26125327

7

Structure-kinetics relationships of Capadenoson derivatives as adenosine A1 receptor agonists.

Louvel J, Guo D, Soethoudt M, Mocking TA, Lenselink EB, Mulder-Krieger T, Heitman LH, IJzerman AP. Louvel J, et al. Among authors: heitman lh. Eur J Med Chem. 2015 Aug 28;101:681-91. doi: 10.1016/j.ejmech.2015.07.023. Epub 2015 Jul 15. Eur J Med Chem. 2015. PMID: 26210506

8

Molecular Basis of Ligand Dissociation from the Adenosine A2A Receptor.

Guo D, Pan AC, Dror RO, Mocking T, Liu R, Heitman LH, Shaw DE, IJzerman AP. Guo D, et al. Among authors: heitman lh. Mol Pharmacol. 2016 May;89(5):485-91. doi: 10.1124/mol.115.102657. Epub 2016 Feb 12. Mol Pharmacol. 2016. PMID: 26873858

9

Synthesis and biological evaluation of chemokine receptor ligands with 2-benzazepine scaffold.

Thum S, Kokornaczyk AK, Seki T, De Maria M, Ortiz Zacarias NV, de Vries H, Weiss C, Koch M, Schepmann D, Kitamura M, Tschammer N, Heitman LH, Junker A, Wünsch B. Thum S, et al. Among authors: heitman lh. Eur J Med Chem. 2017 Jul 28;135:401-413. doi: 10.1016/j.ejmech.2017.04.046. Epub 2017 Apr 22. Eur J Med Chem. 2017. PMID: 28463783

10

Structure-Affinity Relationships and Structure-Kinetics Relationships of Pyrido[2,1-f]purine-2,4-dione Derivatives as Human Adenosine A₃ Receptor Antagonists.

Xia L, Burger WAC, van Veldhoven JPD, Kuiper BJ, van Duijl TT, Lenselink EB, Paasman E, Heitman LH, IJzerman AP. Xia L, et al. Among authors: heitman lh. J Med Chem. 2017 Sep 14;60(17):7555-7568. doi: 10.1021/acs.jmedchem.7b00950. Epub 2017 Aug 30. J Med Chem. 2017. PMID: 28806076 Free PMC article.

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