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Identification, structural, and biophysical characterization of a positive modulator of human Kv3.1 channels.
Proc Natl Acad Sci U S A. 2023 Oct 17;120(42):e2220029120. doi: 10.1073/pnas.2220029120. Epub 2023 Oct 9.
Proc Natl Acad Sci U S A. 2023.
PMID: 37812700
Free PMC article.
Structure-Guided Design and Procognitive Assessment of a Potent and Selective Phosphodiesterase 2A Inhibitor.
Stachel SJ, Berger R, Nomland AB, Ginnetti AT, Paone DV, Wang D, Puri V, Lange H, Drott J, Lu J, Marcus J, Dwyer MP, Suon S, Uslaner JM, Smith SM.
Stachel SJ, et al. Among authors: ginnetti at.
ACS Med Chem Lett. 2018 Jul 26;9(8):815-820. doi: 10.1021/acsmedchemlett.8b00214. eCollection 2018 Aug 9.
ACS Med Chem Lett. 2018.
PMID: 30128073
Free PMC article.
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Identification of potent inhibitors of the sortilin-progranulin interaction.
Stachel SJ, Ginnetti AT, Johnson SA, Cramer P, Wang Y, Bukhtiyarova M, Krosky D, Stump C, Hurzy DM, Schlegel KA, Cooke AJ, Allen S, O'Donnell G, Ziebell M, Parthasarathy G, Getty KL, Ho T, Ou Y, Jovanovska A, Carroll SS, Pausch M, Lumb K, Mosser SD, Voleti B, Klein DJ, Soisson SM, Zerbinatti C, Coleman PJ.
Stachel SJ, et al. Among authors: ginnetti at.
Bioorg Med Chem Lett. 2020 Sep 1;30(17):127403. doi: 10.1016/j.bmcl.2020.127403. Epub 2020 Jul 15.
Bioorg Med Chem Lett. 2020.
PMID: 32738972
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Lead optimization of cathepsin K inhibitors for the treatment of Osteoarthritis.
Ginnetti AT, Paone DV, Nanda KK, Li J, Busuek M, Johnson SA, Lu J, Soisson SM, Robinson R, Fisher J, Webber A, Wesolowski G, Ma B, Duong L, Carroll S, Burgey CS, Stachel SJ.
Ginnetti AT, et al.
Bioorg Med Chem Lett. 2022 Oct 15;74:128927. doi: 10.1016/j.bmcl.2022.128927. Epub 2022 Aug 6.
Bioorg Med Chem Lett. 2022.
PMID: 35944849
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Base-Mediated Oxidative Degradation of Secondary Amides Derived from p-Amino Phenol to Primary Amides in Drug Molecules.
Nanda KK, Ginnetti A, Wuelfing WP.
Nanda KK, et al.
J Pharm Sci. 2020 Nov;109(11):3394-3403. doi: 10.1016/j.xphs.2020.07.028. Epub 2020 Aug 3.
J Pharm Sci. 2020.
PMID: 32758546
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Identification of second-generation P2X3 antagonists for treatment of pain.
Ginnetti AT, Paone DV, Stauffer SR, Potteiger CM, Shaw AW, Deng J, Mulhearn JJ, Nguyen DN, Segerdell C, Anquandah J, Calamari A, Cheng G, Leitl MD, Liang A, Moore E, Panigel J, Urban M, Wang J, Fillgrove K, Tang C, Cook S, Kane S, Salvatore CA, Graham SL, Burgey CS.
Ginnetti AT, et al.
Bioorg Med Chem Lett. 2018 May 1;28(8):1392-1396. doi: 10.1016/j.bmcl.2018.02.039. Epub 2018 Feb 21.
Bioorg Med Chem Lett. 2018.
PMID: 29548573
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Copper-facilitated Suzuki reactions: application to 2-heterocyclic boronates.
Deng JZ, Paone DV, Ginnetti AT, Kurihara H, Dreher SD, Weissman SA, Stauffer SR, Burgey CS.
Deng JZ, et al. Among authors: ginnetti at.
Org Lett. 2009 Jan 15;11(2):345-7. doi: 10.1021/ol802556f.
Org Lett. 2009.
PMID: 19093828
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Orally available nucleoside analog UMM-766 provides protection in a murine model of orthopox disease.
Mudhasani RR, Golden JW, Adam GC, Hartingh TJ, Kota KP, Ordonez D, Quackenbush CR, Tran JP, Cline C, Williams JA, Zeng X, Olsen DB, Lieberman LA, Boyce C, Ginnetti A, Meinig JM, Panchal RG, Mucker EM.
Mudhasani RR, et al.
Microbiol Spectr. 2024 Apr 2;12(4):e0358623. doi: 10.1128/spectrum.03586-23. Epub 2024 Feb 23.
Microbiol Spectr. 2024.
PMID: 38391232
Free PMC article.
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