Fortin S - Search Results

1

Homologation of the Alkyl Side Chain of Antimitotic Phenyl 4-(2-Oxo-3-alkylimidazolidin-1-yl)benzenesulfonate Prodrugs Selectively Targeting CYP1A1-Expressing Breast Cancers Improves Their Stability in Rodent Liver Microsomes.

Chavez Alvarez AC, Bouzriba C, Moreau E, Auzeloux P, Besse S, Ouellette V, Zarifi Khosroshahi M, Côté MF, Pilote S, Miot-Noirault E, Chezal JM, Simard C, C-Gaudreault R, Fortin S. Chavez Alvarez AC, et al. Among authors: fortin s. J Med Chem. 2023 Feb 23;66(4):2477-2497. doi: 10.1021/acs.jmedchem.2c01268. Epub 2023 Feb 13. J Med Chem. 2023. PMID: 36780426

2

Optimized N-phenyl-N'-(2-chloroethyl)ureas as potential antineoplastic agents: synthesis and growth inhibition activity.

Moreau E, Fortin S, Desjardins M, Rousseau JL, Petitclerc E, C-Gaudreault R. Moreau E, et al. Among authors: fortin s. Bioorg Med Chem. 2005 Dec 15;13(24):6703-12. doi: 10.1016/j.bmc.2005.07.048. Epub 2005 Sep 13. Bioorg Med Chem. 2005. PMID: 16165366

3

N-Phenyl-N'-(2-chloroethyl)ureas (CEU) as potential antineoplastic agents. Part 2: role of omega-hydroxyl group in the covalent binding to beta-tubulin.

Fortin S, Moreau E, Patenaude A, Desjardins M, Lacroix J, Rousseau JL, C-Gaudreault R. Fortin S, et al. Bioorg Med Chem. 2007 Feb 1;15(3):1430-8. doi: 10.1016/j.bmc.2006.11.005. Epub 2006 Nov 10. Bioorg Med Chem. 2007. PMID: 17118664

4

N-Phenyl-N'-(2-chloroethyl)urea analogues of combretastatin A-4: Is the N-phenyl-N'-(2-chloroethyl)urea pharmacophore mimicking the trimethoxy phenyl moiety?

Fortin S, Moreau E, Lacroix J, Teulade JC, Patenaude A, C-Gaudreault R. Fortin S, et al. Bioorg Med Chem Lett. 2007 Apr 1;17(7):2000-4. doi: 10.1016/j.bmcl.2007.01.023. Epub 2007 Jan 19. Bioorg Med Chem Lett. 2007. PMID: 17291753

5

N-Phenyl-N'-(2-chloroethyl)ureas (CEUs) as potential antineoplastic agents. Part 3: role of carbonyl groups in the covalent binding to the colchicine-binding site.

Moreau E, Fortin S, Lacroix J, Patenaude A, Rousseau JL, C-Gaudreault R. Moreau E, et al. Among authors: fortin s. Bioorg Med Chem. 2008 Feb 1;16(3):1206-17. doi: 10.1016/j.bmc.2007.10.078. Epub 2007 Nov 12. Bioorg Med Chem. 2008. PMID: 17998163

6

A comparative molecular field and comparative molecular similarity indices analyses (CoMFA and CoMSIA) of N-phenyl-N'-(2-chloroethyl)ureas targeting the colchicine-binding site as anticancer agents.

Fortin S, Labrie P, Moreau E, Wei L, Kotra LP, C-Gaudreault R. Fortin S, et al. Bioorg Med Chem. 2008 Feb 15;16(4):1914-26. doi: 10.1016/j.bmc.2007.11.004. Epub 2007 Nov 5. Bioorg Med Chem. 2008. PMID: 18023585

7

Mechanism of action of N-phenyl-N'-(2-chloroethyl)ureas in the colchicine-binding site at the interface between alpha- and beta-tubulin.

Fortin S, Wei L, Moreau E, Labrie P, Petitclerc E, Kotra LP, C-Gaudreault R. Fortin S, et al. Bioorg Med Chem. 2009 May 15;17(10):3690-7. doi: 10.1016/j.bmc.2009.03.056. Epub 2009 Apr 1. Bioorg Med Chem. 2009. PMID: 19398206

8

Effects of inactivation-resistant agonists on the signalling, desensitization and down-regulation of bradykinin B(2) receptors.

Bawolak MT, Fortin S, Bouthillier J, Adam A, Gera L, C-Gaudreault R, Marceau F. Bawolak MT, et al. Among authors: fortin s. Br J Pharmacol. 2009 Nov;158(5):1375-86. doi: 10.1111/j.1476-5381.2009.00409.x. Epub 2009 Sep 28. Br J Pharmacol. 2009. PMID: 19785654 Free PMC article.

9

Synthesis, antiproliferative activity evaluation and structure-activity relationships of novel aromatic urea and amide analogues of N-phenyl-N'-(2-chloroethyl)ureas.

Fortin S, Moreau E, Lacroix J, Côté MF, Petitclerc E, C-Gaudreault R. Fortin S, et al. Eur J Med Chem. 2010 Jul;45(7):2928-37. doi: 10.1016/j.ejmech.2010.03.018. Epub 2010 Mar 25. Eur J Med Chem. 2010. PMID: 20400211

10

Characterization of the covalent binding of N-phenyl-N'-(2-chloroethyl)ureas to {beta}-tubulin: importance of Glu198 in microtubule stability.

Fortin S, Bouchon B, Chambon C, Lacroix J, Moreau E, Chezal JM, Degoul F, C-Gaudreault R. Fortin S, et al. J Pharmacol Exp Ther. 2011 Feb;336(2):460-7. doi: 10.1124/jpet.110.171082. Epub 2010 Oct 26. J Pharmacol Exp Ther. 2011. PMID: 20978170

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