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Skeletal muscle derived Musclin protects the heart during pathological overload.
Szaroszyk M, Kattih B, Martin-Garrido A, Trogisch FA, Dittrich GM, Grund A, Abouissa A, Derlin K, Meier M, Holler T, Korf-Klingebiel M, Völker K, Garfias Macedo T, Pablo Tortola C, Boschmann M, Huang N, Froese N, Zwadlo C, Malek Mohammadi M, Luo X, Wagner M, Cordero J, Geffers R, Batkai S, Thum T, Bork N, Nikolaev VO, Müller OJ, Katus HA, El-Armouche A, Kraft T, Springer J, Dobreva G, Wollert KC, Fielitz J, von Haehling S, Kuhn M, Bauersachs J, Heineke J. Szaroszyk M, et al. Nat Commun. 2022 Jan 10;13(1):149. doi: 10.1038/s41467-021-27634-5. Nat Commun. 2022. PMID: 35013221 Free PMC article.
PDE2-mediated cAMP hydrolysis accelerates cardiac fibroblast to myofibroblast conversion and is antagonized by exogenous activation of cGMP signaling pathways.
Vettel C, Lämmle S, Ewens S, Cervirgen C, Emons J, Ongherth A, Dewenter M, Lindner D, Westermann D, Nikolaev VO, Lutz S, Zimmermann WH, El-Armouche A. Vettel C, et al. Am J Physiol Heart Circ Physiol. 2014 Apr 15;306(8):H1246-52. doi: 10.1152/ajpheart.00852.2013. Epub 2014 Feb 14. Am J Physiol Heart Circ Physiol. 2014. PMID: 24531807 Free article.
[Off-label-drug-use: Scientific evidence counts].
Wagner M, El-Armouche A. Wagner M, et al. Dtsch Med Wochenschr. 2016 Mar;141(5):307. doi: 10.1055/s-0042-101364. Epub 2016 Mar 3. Dtsch Med Wochenschr. 2016. PMID: 26939091 German. No abstract available.
Redox Imaging Using Cardiac Myocyte-Specific Transgenic Biosensor Mice.
Swain L, Kesemeyer A, Meyer-Roxlau S, Vettel C, Zieseniss A, Güntsch A, Jatho A, Becker A, Nanadikar MS, Morgan B, Dennerlein S, Shah AM, El-Armouche A, Nikolaev VO, Katschinski DM. Swain L, et al. Circ Res. 2016 Oct 14;119(9):1004-1016. doi: 10.1161/CIRCRESAHA.116.309551. Epub 2016 Aug 23. Circ Res. 2016. PMID: 27553648
140 results