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Modification of γ-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease.
Guix FX, Wahle T, Vennekens K, Snellinx A, Chávez-Gutiérrez L, Ill-Raga G, Ramos-Fernandez E, Guardia-Laguarta C, Lleó A, Arimon M, Berezovska O, Muñoz FJ, Dotti CG, De Strooper B. Guix FX, et al. Among authors: de strooper b. EMBO Mol Med. 2012 Jul;4(7):660-73. doi: 10.1002/emmm.201200243. Epub 2012 May 2. EMBO Mol Med. 2012. PMID: 22488900 Free PMC article.
The Cellular Phase of Alzheimer's Disease.
De Strooper B, Karran E. De Strooper B, et al. Cell. 2016 Feb 11;164(4):603-15. doi: 10.1016/j.cell.2015.12.056. Cell. 2016. PMID: 26871627 Free article. Review.
microRNA-132: a key noncoding RNA operating in the cellular phase of Alzheimer's disease.
Salta E, De Strooper B. Salta E, et al. Among authors: de strooper b. FASEB J. 2017 Feb;31(2):424-433. doi: 10.1096/fj.201601308. FASEB J. 2017. PMID: 28148775 Review.
We describe the potential therapeutic implications of these findings and suggest miRNA targeting or replacement as a realistic multi-hit, therapeutic strategy for AD. Salta, E., De Strooper, B. microRNA-132: a key noncoding RNA operating in the cellular phase …
We describe the potential therapeutic implications of these findings and suggest miRNA targeting or replacement as a realistic multi-hit, th …
The Major Risk Factors for Alzheimer's Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques.
Sala Frigerio C, Wolfs L, Fattorelli N, Thrupp N, Voytyuk I, Schmidt I, Mancuso R, Chen WT, Woodbury ME, Srivastava G, Möller T, Hudry E, Das S, Saido T, Karran E, Hyman B, Perry VH, Fiers M, De Strooper B. Sala Frigerio C, et al. Among authors: de strooper b. Cell Rep. 2019 Apr 23;27(4):1293-1306.e6. doi: 10.1016/j.celrep.2019.03.099. Cell Rep. 2019. PMID: 31018141 Free PMC article.
Alzheimer's disease.
Scheltens P, De Strooper B, Kivipelto M, Holstege H, Chételat G, Teunissen CE, Cummings J, van der Flier WM. Scheltens P, et al. Among authors: de strooper b. Lancet. 2021 Apr 24;397(10284):1577-1590. doi: 10.1016/S0140-6736(20)32205-4. Epub 2021 Mar 2. Lancet. 2021. PMID: 33667416 Free PMC article. Review.
395 results