Cellular senescence at the crossroads of inflammation and Alzheimer's disease

Ana Guerrero; Bart De Strooper; I Lorena Arancibia-Cárcamo

doi:10.1016/j.tins.2021.06.007

Cellular senescence at the crossroads of inflammation and Alzheimer's disease

Trends Neurosci. 2021 Sep;44(9):714-727. doi: 10.1016/j.tins.2021.06.007. Epub 2021 Aug 5.

Authors

Ana Guerrero¹, Bart De Strooper², I Lorena Arancibia-Cárcamo³

Affiliations

¹ UK Dementia Research Institute, Institute of Neurology, University College London, London WC1E 6BT, UK; The Francis Crick Institute, London NW1 1AT, UK.
² UK Dementia Research Institute, Institute of Neurology, University College London, London WC1E 6BT, UK; The Francis Crick Institute, London NW1 1AT, UK; Department of Neurosciences, Leuven Brain Institute, Katholieke Universiteit (KU) Leuven, Leuven, Belgium; Vlaams Instituut voor Biotechnologie (VIB) Centre for Brain and Disease Research, Leuven, Belgium.
³ UK Dementia Research Institute, Institute of Neurology, University College London, London WC1E 6BT, UK; The Francis Crick Institute, London NW1 1AT, UK. Electronic address: lorena.arancibia@ukdri.ac.uk.

PMID: 34366147
DOI: 10.1016/j.tins.2021.06.007

Abstract

Aging is a key risk factor for Alzheimer's disease (AD), but the reasons for this association are not well understood. Senescent cells accumulate in aged tissues and have been shown to play causal roles in age-related pathologies through their proinflammatory secretome. The question arises whether senescence-induced inflammation might contribute to AD and bridge the gap between aging and AD. Here, we highlight the role of cellular senescence as a driver of the aging phenotype, and discuss the current evidence that connects senescence with AD and neurodegeneration.

Trial registration: ClinicalTrials.gov NCT04785300 NCT04685590.

Keywords: SASP; aging; astrocytes; microglia; neurodegeneration; neuroinflammation.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Aged
Aging
Alzheimer Disease*
Cellular Senescence
Humans
Inflammation
Phenotype

Associated data

ClinicalTrials.gov/NCT04785300
ClinicalTrials.gov/NCT04685590

Grants and funding

MRC_/Medical Research Council/United Kingdom