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Regulation of eDHFR-tagged proteins with trimethoprim PROTACs.
Etersque JM, Lee IK, Sharma N, Xu K, Ruff A, Northrup JD, Sarkar S, Nguyen T, Lauman R, Burslem GM, Sellmyer MA. Etersque JM, et al. Nat Commun. 2023 Nov 3;14(1):7071. doi: 10.1038/s41467-023-42820-3. Nat Commun. 2023. PMID: 37923771 Free PMC article.
Imaging sensitive and drug-resistant bacterial infection with [11C]-trimethoprim.
Lee IK, Jacome DA, Cho JK, Tu V, Young AJ, Dominguez T, Northrup JD, Etersque JM, Lee HS, Ruff A, Aklilu O, Bittinger K, Glaser LJ, Dorgan D, Hadjiliadis D, Kohli RM, Mach RH, Mankoff DA, Doot RK, Sellmyer MA. Lee IK, et al. J Clin Invest. 2022 Sep 15;132(18):e156679. doi: 10.1172/JCI156679. J Clin Invest. 2022. PMID: 36106638 Free PMC article.
Monitoring Therapeutic Response to Anti-FAP CAR T Cells Using [18F]AlF-FAPI-74.
Lee IK, Noguera-Ortega E, Xiao Z, Todd L, Scholler J, Song D, Liousia M, Lohith K, Xu K, Edwards KJ, Farwell MD, June CH, Albelda SM, Puré E, Sellmyer MA. Lee IK, et al. Clin Cancer Res. 2022 Dec 15;28(24):5330-5342. doi: 10.1158/1078-0432.CCR-22-1379. Clin Cancer Res. 2022. PMID: 35972732 Free PMC article.
Imaging CAR T Cell Trafficking with eDHFR as a PET Reporter Gene.
Sellmyer MA, Richman SA, Lohith K, Hou C, Weng CC, Mach RH, O'Connor RS, Milone MC, Farwell MD. Sellmyer MA, et al. Mol Ther. 2020 Jan 8;28(1):42-51. doi: 10.1016/j.ymthe.2019.10.007. Epub 2019 Oct 15. Mol Ther. 2020. PMID: 31668558 Free PMC article.