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Novel Compounds Targeting the RNA-Binding Protein HuR. Structure-Based Design, Synthesis, and Interaction Studies.
Della Volpe S, Nasti R, Queirolo M, Unver MY, Jumde VK, Dömling A, Vasile F, Potenza D, Ambrosio FA, Costa G, Alcaro S, Zucal C, Provenzani A, Di Giacomo M, Rossi D, Hirsch AKH, Collina S. Della Volpe S, et al. Among authors: domling a. ACS Med Chem Lett. 2019 Jan 21;10(4):615-620. doi: 10.1021/acsmedchemlett.8b00600. eCollection 2019 Apr 11. ACS Med Chem Lett. 2019. PMID: 30996806 Free PMC article.
Atorvastatin (Lipitor) by MCR.
Zarganes-Tzitzikas T, Neochoritis CG, Dömling A. Zarganes-Tzitzikas T, et al. Among authors: domling a. ACS Med Chem Lett. 2019 Feb 7;10(3):389-392. doi: 10.1021/acsmedchemlett.8b00579. eCollection 2019 Mar 14. ACS Med Chem Lett. 2019. PMID: 30891146 Free PMC article.
Optimized Inhibitors of MDM2 via an Attempted Protein-Templated Reductive Amination.
van der Vlag R, Yagiz Unver M, Felicetti T, Twarda-Clapa A, Kassim F, Ermis C, Neochoritis CG, Musielak B, Labuzek B, Dömling A, Holak TA, Hirsch AKH. van der Vlag R, et al. Among authors: domling a. ChemMedChem. 2020 Feb 17;15(4):370-375. doi: 10.1002/cmdc.201900574. Epub 2019 Dec 12. ChemMedChem. 2020. PMID: 31774938 Free PMC article.
Rapid Discovery of Aspartyl Protease Inhibitors Using an Anchoring Approach.
Konstantinidou M, Magari F, Sutanto F, Haupenthal J, Jumde VR, Ünver MY, Heine A, Camacho CJ, Hirsch AKH, Klebe G, Dömling A. Konstantinidou M, et al. Among authors: domling a. ChemMedChem. 2020 Apr 20;15(8):680-684. doi: 10.1002/cmdc.202000024. Epub 2020 Mar 18. ChemMedChem. 2020. PMID: 32187447 Free PMC article.
Design, Synthesis, and Biological Evaluation of Imidazopyridines as PD-1/PD-L1 Antagonists.
Butera R, Ważyńska M, Magiera-Mularz K, Plewka J, Musielak B, Surmiak E, Sala D, Kitel R, de Bruyn M, Nijman HW, Elsinga PH, Holak TA, Dömling A. Butera R, et al. Among authors: domling a. ACS Med Chem Lett. 2021 Apr 28;12(5):768-773. doi: 10.1021/acsmedchemlett.1c00033. eCollection 2021 May 13. ACS Med Chem Lett. 2021. PMID: 34055224 Free PMC article.
Multicomponent Macrocyclic IL-17a Modifier.
Abdelraheem E, Lubberink M, Wang W, Li J, Reyes Romero A, van der Straat R, Du X, Groves M, Dömling A. Abdelraheem E, et al. Among authors: domling a. ACS Med Chem Lett. 2022 Aug 12;13(9):1468-1471. doi: 10.1021/acsmedchemlett.2c00257. eCollection 2022 Sep 8. ACS Med Chem Lett. 2022. PMID: 36105327 Free PMC article.
2,30-Bis(10H-indole) heterocycles: New p53/MDM2/MDMX antagonists.
Neochoritis CG, Wang K, Estrada-Ortiz N, Herdtweck E, Kubica K, Twarda A, Zak KM, Holak TA, Dömling A. Neochoritis CG, et al. Among authors: domling a. Bioorg Med Chem Lett. 2015 Dec 15;25(24):5661-6. doi: 10.1016/j.bmcl.2015.11.019. Bioorg Med Chem Lett. 2015. PMID: 26584879 Free PMC article.
260 results