Identification of Hsp70 modulators through modeling of the substrate binding domain

Conor M Haney; Corinne Schneider; Barbara Beck; Jeffrey L Brodsky; Alexander Dömling

doi:10.1016/j.bmcl.2009.04.062

Identification of Hsp70 modulators through modeling of the substrate binding domain

Bioorg Med Chem Lett. 2009 Jul 15;19(14):3828-31. doi: 10.1016/j.bmcl.2009.04.062. Epub 2009 Apr 20.

Authors

Conor M Haney¹, Corinne Schneider, Barbara Beck, Jeffrey L Brodsky, Alexander Dömling

Affiliation

¹ Department of Pharmacy, University of Pittsburgh, Pittsburgh, USA.

Abstract

The design, synthesis and preliminary activity of small molecular weight modulators of the heat shock protein 70 (Hsp70) are described. The compounds provide a starting point for the synthesis of novel tools to decipher Hsp70 biology.

MeSH terms

Amino Acid Sequence
Binding Sites
Computer Simulation
Crystallography, X-Ray
HSP70 Heat-Shock Proteins / chemistry*
HSP70 Heat-Shock Proteins / metabolism
Models, Chemical
Peptides / chemical synthesis
Peptides / chemistry*
Peptides / pharmacology
Protein Binding
Protein Structure, Tertiary

Substances

HSP70 Heat-Shock Proteins
Peptides

Grants and funding

R01 GM075061/GM/NIGMS NIH HHS/United States