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Therapeutic potential for coxibs-nitric oxide releasing hybrids in cystic fibrosis.
Consalvi S, Poce G, Ghelardini C, Di Cesare Mannelli L, Patrignani P, Bruno A, Anzini M, Calderone V, Martelli A, Testai L, Giordani A, Biava M. Consalvi S, et al. Eur J Med Chem. 2021 Jan 15;210:112983. doi: 10.1016/j.ejmech.2020.112983. Epub 2020 Oct 31. Eur J Med Chem. 2021. PMID: 33168231 Review.
Improving the solubility of a new class of antiinflammatory pharmacodynamic hybrids, that release nitric oxide and inhibit cycloxygenase-2 isoenzyme.
Biava M, Battilocchio C, Poce G, Alfonso S, Consalvi S, Porretta GC, Schenone S, Calderone V, Martelli A, Testai L, Ghelardini C, Di Cesare Mannelli L, Sautebin L, Rossi A, Giordani A, Patrignani P, Anzini M. Biava M, et al. Among authors: consalvi s. Eur J Med Chem. 2012 Dec;58:287-98. doi: 10.1016/j.ejmech.2012.10.014. Epub 2012 Oct 18. Eur J Med Chem. 2012. PMID: 23131542
A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity.
Battilocchio C, Poce G, Alfonso S, Porretta GC, Consalvi S, Sautebin L, Pace S, Rossi A, Ghelardini C, Di Cesare Mannelli L, Schenone S, Giordani A, Di Francesco L, Patrignani P, Biava M. Battilocchio C, et al. Among authors: consalvi s. Bioorg Med Chem. 2013 Jul 1;21(13):3695-701. doi: 10.1016/j.bmc.2013.04.031. Epub 2013 Apr 26. Bioorg Med Chem. 2013. PMID: 23680444
The novel anti-inflammatory agent VA694, endowed with both NO-releasing and COX2-selective inhibiting properties, exhibits NO-mediated positive effects on blood pressure, coronary flow and endothelium in an experimental model of hypertension and endothelial dysfunction.
Martelli A, Testai L, Anzini M, Cappelli A, Di Capua A, Biava M, Poce G, Consalvi S, Giordani A, Caselli G, Rovati L, Ghelardini C, Patrignani P, Sautebin L, Breschi MC, Calderone V. Martelli A, et al. Among authors: consalvi s. Pharmacol Res. 2013 Dec;78:1-9. doi: 10.1016/j.phrs.2013.09.008. Epub 2013 Sep 29. Pharmacol Res. 2013. PMID: 24083950
Enhancing the pharmacodynamic profile of a class of selective COX-2 inhibiting nitric oxide donors.
Biava M, Battilocchio C, Poce G, Alfonso S, Consalvi S, Di Capua A, Calderone V, Martelli A, Testai L, Sautebin L, Rossi A, Ghelardini C, Di Cesare Mannelli L, Giordani A, Persiani S, Colovic M, Dovizio M, Patrignani P, Anzini M. Biava M, et al. Among authors: consalvi s. Bioorg Med Chem. 2014 Jan 15;22(2):772-86. doi: 10.1016/j.bmc.2013.12.008. Epub 2013 Dec 18. Bioorg Med Chem. 2014. PMID: 24373735
Synthesis, biological evaluation and docking analysis of a new series of methylsulfonyl and sulfamoyl acetamides and ethyl acetates as potent COX-2 inhibitors.
Consalvi S, Alfonso S, Di Capua A, Poce G, Pirolli A, Sabatino M, Ragno R, Anzini M, Sartini S, La Motta C, Di Cesare Mannelli L, Ghelardini C, Biava M. Consalvi S, et al. Bioorg Med Chem. 2015 Feb 15;23(4):810-20. doi: 10.1016/j.bmc.2014.12.041. Epub 2014 Dec 26. Bioorg Med Chem. 2015. PMID: 25596758
COX inhibitors: a patent review (2011 - 2014).
Consalvi S, Biava M, Poce G. Consalvi S, et al. Expert Opin Ther Pat. 2015;25(12):1357-71. doi: 10.1517/13543776.2015.1090973. Epub 2015 Nov 13. Expert Opin Ther Pat. 2015. PMID: 26566186 Review.
41 results