Therapeutic potential for coxibs-nitric oxide releasing hybrids in cystic fibrosis

Sara Consalvi; Giovanna Poce; Carla Ghelardini; Lorenzo Di Cesare Mannelli; Paola Patrignani; Annalisa Bruno; Maurizio Anzini; Vincenzo Calderone; Alma Martelli; Lara Testai; Antonio Giordani; Mariangela Biava

doi:10.1016/j.ejmech.2020.112983

Therapeutic potential for coxibs-nitric oxide releasing hybrids in cystic fibrosis

Eur J Med Chem. 2021 Jan 15:210:112983. doi: 10.1016/j.ejmech.2020.112983. Epub 2020 Oct 31.

Affiliations

¹ Department of Chemistry and Technologies of Drug, Sapienza University of Rome, Piazzale A. Moro 5, 00185, Rome, Italy.
² Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Via Schiff 6, Sesto Fiorentino, 50019, Florence, Italy.
³ Department of Neuroscience, Imaging and Clinical Sciences, And Center for Advanced Studies and Technology (CAST), School of Medicine, G. D'Annunzio University, Chieti, Italy.
⁴ Department of Biotechnology, Chemistry, And Pharmacy, DoE 2018-2022, University of Siena, 53100, Siena, Italy.
⁵ Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126, Pisa, Italy.
⁶ Formerly Rottapharm at the Present Consultant, Italy.
⁷ Department of Chemistry and Technologies of Drug, Sapienza University of Rome, Piazzale A. Moro 5, 00185, Rome, Italy. Electronic address: mariangela.biava@uniroma1.it.

PMID: 33168231
DOI: 10.1016/j.ejmech.2020.112983

Abstract

This review discusses the rational for further studies of COX-2 inhibitors-NO releaser hybrids (NO-Coxibs) in the pharmacological treatment of the airway inflammation in Cystic Fibrosis (CF). Our research group developed several classes of NO-Coxibs for the pharmacological treatment of arthritis, and among them several compounds showed an outstanding in vivo efficacy and good pharmacokinetic properties. The good antiinflammatory properties displayed by these compounds during the previous screening could, by itself, suggest appropriate candidates for further testing in CF.

Keywords: CINODs; COX-2; Cystic fibrosis; Inflammation.

Publication types

Review

MeSH terms

Animals
Anti-Inflammatory Agents, Non-Steroidal / chemistry
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
Cyclooxygenase 2 / metabolism
Cyclooxygenase 2 Inhibitors / chemistry
Cyclooxygenase 2 Inhibitors / pharmacology*
Cystic Fibrosis / drug therapy*
Cystic Fibrosis / metabolism
Humans
Inflammation / drug therapy
Inflammation / metabolism
Molecular Structure
Nitric Oxide / chemistry
Nitric Oxide / pharmacology*

Substances

Anti-Inflammatory Agents, Non-Steroidal
Cyclooxygenase 2 Inhibitors
Nitric Oxide
Cyclooxygenase 2