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Dynamic interplay between catalytic and lectin domains of GalNAc-transferases modulates protein O-glycosylation.
Lira-Navarrete E, de Las Rivas M, Compañón I, Pallarés MC, Kong Y, Iglesias-Fernández J, Bernardes GJ, Peregrina JM, Rovira C, Bernadó P, Bruscolini P, Clausen H, Lostao A, Corzana F, Hurtado-Guerrero R. Lira-Navarrete E, et al. Among authors: companon i. Nat Commun. 2015 May 5;6:6937. doi: 10.1038/ncomms7937. Nat Commun. 2015. PMID: 25939779 Free PMC article.
Structural basis for the synthesis of the core 1 structure by C1GalT1.
González-Ramírez AM, Grosso AS, Yang Z, Compañón I, Coelho H, Narimatsu Y, Clausen H, Marcelo F, Corzana F, Hurtado-Guerrero R. González-Ramírez AM, et al. Among authors: companon i. Nat Commun. 2022 May 3;13(1):2398. doi: 10.1038/s41467-022-29833-0. Nat Commun. 2022. PMID: 35504880 Free PMC article.
The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences.
de Las Rivas M, Lira-Navarrete E, Daniel EJP, Compañón I, Coelho H, Diniz A, Jiménez-Barbero J, Peregrina JM, Clausen H, Corzana F, Marcelo F, Jiménez-Osés G, Gerken TA, Hurtado-Guerrero R. de Las Rivas M, et al. Among authors: companon i. Nat Commun. 2017 Dec 5;8(1):1959. doi: 10.1038/s41467-017-02006-0. Nat Commun. 2017. PMID: 29208955 Free PMC article.
Molecular basis for fibroblast growth factor 23 O-glycosylation by GalNAc-T3.
de Las Rivas M, Paul Daniel EJ, Narimatsu Y, Compañón I, Kato K, Hermosilla P, Thureau A, Ceballos-Laita L, Coelho H, Bernadó P, Marcelo F, Hansen L, Maeda R, Lostao A, Corzana F, Clausen H, Gerken TA, Hurtado-Guerrero R. de Las Rivas M, et al. Among authors: companon i. Nat Chem Biol. 2020 Mar;16(3):351-360. doi: 10.1038/s41589-019-0444-x. Epub 2020 Jan 13. Nat Chem Biol. 2020. PMID: 31932717 Free PMC article.
Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibody.
Macías-León J , Bermejo IA , Asín A , García-García A , Compañón I , Jiménez-Moreno E , Coelho H , Mangini V , Albuquerque IS , Marcelo F , Asensio JL , Bernardes GJL , Joshi HJ , Fiammengo R , Blixt O , Hurtado-Guerrero R , Corzana F . Macías-León J , et al. Among authors: companon i. Chem Commun (Camb). 2020 Dec 8;56(96):15137-15140. doi: 10.1039/d0cc06349e. Chem Commun (Camb). 2020. PMID: 33211039
Structural and Mechanistic Insights into the Catalytic-Domain-Mediated Short-Range Glycosylation Preferences of GalNAc-T4.
de Las Rivas M, Paul Daniel EJ, Coelho H, Lira-Navarrete E, Raich L, Compañón I, Diniz A, Lagartera L, Jiménez-Barbero J, Clausen H, Rovira C, Marcelo F, Corzana F, Gerken TA, Hurtado-Guerrero R. de Las Rivas M, et al. Among authors: companon i. ACS Cent Sci. 2018 Sep 26;4(9):1274-1290. doi: 10.1021/acscentsci.8b00488. Epub 2018 Sep 14. ACS Cent Sci. 2018. PMID: 30276263 Free PMC article.
Substrate-guided front-face reaction revealed by combined structural snapshots and metadynamics for the polypeptide N-acetylgalactosaminyltransferase 2.
Lira-Navarrete E, Iglesias-Fernández J, Zandberg WF, Compañón I, Kong Y, Corzana F, Pinto BM, Clausen H, Peregrina JM, Vocadlo DJ, Rovira C, Hurtado-Guerrero R. Lira-Navarrete E, et al. Among authors: companon i. Angew Chem Int Ed Engl. 2014 Jul 28;53(31):8206-10. doi: 10.1002/anie.201402781. Epub 2014 Jun 20. Angew Chem Int Ed Engl. 2014. PMID: 24954443
27 results