Abstract
The molecular basis of antibody 5E5, which recognizes the entire GalNAc unit as a primary epitope is disclosed. The antibody's contacts with the peptide are mostly limited to two residues, allowing it to show some degree of promiscuity. These findings open the door to the chemical design of peptide-mimetics for developing efficient anti-cancer vaccines and diagnostic tools.
MeSH terms
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Antibodies, Monoclonal / chemistry*
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Antibodies, Monoclonal / pharmacology
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology
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Cancer Vaccines / chemistry*
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Cancer Vaccines / pharmacology
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Drug Screening Assays, Antitumor
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Glycopeptides / chemistry
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Glycosylation
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Humans
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Hydrogen Bonding
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Lectins / chemistry*
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Lectins / pharmacology
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Molecular Dynamics Simulation
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Mucin-1 / chemistry*
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Peptide Fragments / chemistry
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Protein Conformation
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Structure-Activity Relationship
Substances
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Antibodies, Monoclonal
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Antineoplastic Agents
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Cancer Vaccines
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Glycopeptides
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Lectins
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Mucin-1
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Peptide Fragments