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Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibody.
Macías-León J , Bermejo IA , Asín A , García-García A , Compañón I , Jiménez-Moreno E , Coelho H , Mangini V , Albuquerque IS , Marcelo F , Asensio JL , Bernardes GJL , Joshi HJ , Fiammengo R , Blixt O , Hurtado-Guerrero R , Corzana F . Macías-León J , et al. Among authors: companon i. Chem Commun (Camb). 2020 Dec 8;56(96):15137-15140. doi: 10.1039/d0cc06349e. Chem Commun (Camb). 2020. PMID: 33211039
Substrate-guided front-face reaction revealed by combined structural snapshots and metadynamics for the polypeptide N-acetylgalactosaminyltransferase 2.
Lira-Navarrete E, Iglesias-Fernández J, Zandberg WF, Compañón I, Kong Y, Corzana F, Pinto BM, Clausen H, Peregrina JM, Vocadlo DJ, Rovira C, Hurtado-Guerrero R. Lira-Navarrete E, et al. Among authors: companon i. Angew Chem Int Ed Engl. 2014 Jul 28;53(31):8206-10. doi: 10.1002/anie.201402781. Epub 2014 Jun 20. Angew Chem Int Ed Engl. 2014. PMID: 24954443
Dynamic interplay between catalytic and lectin domains of GalNAc-transferases modulates protein O-glycosylation.
Lira-Navarrete E, de Las Rivas M, Compañón I, Pallarés MC, Kong Y, Iglesias-Fernández J, Bernardes GJ, Peregrina JM, Rovira C, Bernadó P, Bruscolini P, Clausen H, Lostao A, Corzana F, Hurtado-Guerrero R. Lira-Navarrete E, et al. Among authors: companon i. Nat Commun. 2015 May 5;6:6937. doi: 10.1038/ncomms7937. Nat Commun. 2015. PMID: 25939779 Free PMC article.
Deciphering the Non-Equivalence of Serine and Threonine O-Glycosylation Points: Implications for Molecular Recognition of the Tn Antigen by an anti-MUC1 Antibody.
Martínez-Sáez N, Castro-López J, Valero-González J, Madariaga D, Compañón I, Somovilla VJ, Salvadó M, Asensio JL, Jiménez-Barbero J, Avenoza A, Busto JH, Bernardes GJ, Peregrina JM, Hurtado-Guerrero R, Corzana F. Martínez-Sáez N, et al. Among authors: companon i. Angew Chem Int Ed Engl. 2015 Aug 17;54(34):9830-4. doi: 10.1002/anie.201502813. Epub 2015 Jun 26. Angew Chem Int Ed Engl. 2015. PMID: 26118689 Free PMC article.
Oxetane Grafts Installed Site-Selectively on Native Disulfides to Enhance Protein Stability and Activity In Vivo.
Martínez-Sáez N, Sun S, Oldrini D, Sormanni P, Boutureira O, Carboni F, Compañón I, Deery MJ, Vendruscolo M, Corzana F, Adamo R, Bernardes GJL. Martínez-Sáez N, et al. Among authors: companon i. Angew Chem Int Ed Engl. 2017 Nov 20;56(47):14963-14967. doi: 10.1002/anie.201708847. Epub 2017 Oct 20. Angew Chem Int Ed Engl. 2017. PMID: 28968001 Free PMC article.
Enhanced Permeability and Binding Activity of Isobutylene-Grafted Peptides.
Sun S, Compañón I, Martínez-Sáez N, Seixas JD, Boutureira O, Corzana F, Bernardes GJL. Sun S, et al. Among authors: companon i. Chembiochem. 2018 Jan 4;19(1):48-52. doi: 10.1002/cbic.201700586. Epub 2017 Nov 22. Chembiochem. 2018. PMID: 29105291 Free PMC article.
The Use of Fluoroproline in MUC1 Antigen Enables Efficient Detection of Antibodies in Patients with Prostate Cancer.
Somovilla VJ, Bermejo IA, Albuquerque IS, Martínez-Sáez N, Castro-López J, García-Martín F, Compañón I, Hinou H, Nishimura SI, Jiménez-Barbero J, Asensio JL, Avenoza A, Busto JH, Hurtado-Guerrero R, Peregrina JM, Bernardes GJL, Corzana F. Somovilla VJ, et al. Among authors: companon i. J Am Chem Soc. 2017 Dec 20;139(50):18255-18261. doi: 10.1021/jacs.7b09447. Epub 2017 Dec 12. J Am Chem Soc. 2017. PMID: 29166012 Free article.
The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences.
de Las Rivas M, Lira-Navarrete E, Daniel EJP, Compañón I, Coelho H, Diniz A, Jiménez-Barbero J, Peregrina JM, Clausen H, Corzana F, Marcelo F, Jiménez-Osés G, Gerken TA, Hurtado-Guerrero R. de Las Rivas M, et al. Among authors: companon i. Nat Commun. 2017 Dec 5;8(1):1959. doi: 10.1038/s41467-017-02006-0. Nat Commun. 2017. PMID: 29208955 Free PMC article.
27 results