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Homologation of the Alkyl Side Chain of Antimitotic Phenyl 4-(2-Oxo-3-alkylimidazolidin-1-yl)benzenesulfonate Prodrugs Selectively Targeting CYP1A1-Expressing Breast Cancers Improves Their Stability in Rodent Liver Microsomes.
Chavez Alvarez AC, Bouzriba C, Moreau E, Auzeloux P, Besse S, Ouellette V, Zarifi Khosroshahi M, Côté MF, Pilote S, Miot-Noirault E, Chezal JM, Simard C, C-Gaudreault R, Fortin S. Chavez Alvarez AC, et al. Among authors: chezal jm. J Med Chem. 2023 Feb 23;66(4):2477-2497. doi: 10.1021/acs.jmedchem.2c01268. Epub 2023 Feb 13. J Med Chem. 2023. PMID: 36780426
The imidazopyrrolopyridine analogue AG110 is a novel, highly selective inhibitor of pestiviruses that targets the viral RNA-dependent RNA polymerase at a hot spot for inhibition of viral replication.
Paeshuyse J, Chezal JM, Froeyen M, Leyssen P, Dutartre H, Vrancken R, Canard B, Letellier C, Li T, Mittendorfer H, Koenen F, Kerkhofs P, De Clercq E, Herdewijn P, Puerstinger G, Gueiffier A, Chavignon O, Teulade JC, Neyts J. Paeshuyse J, et al. Among authors: chezal jm. J Virol. 2007 Oct;81(20):11046-53. doi: 10.1128/JVI.00388-07. Epub 2007 Aug 8. J Virol. 2007. PMID: 17686854 Free PMC article.
New opportunities with the Duff reaction.
Masurier N, Moreau E, Lartigue C, Gaumet V, Chezal JM, Heitz A, Teulade JC, Chavignon O. Masurier N, et al. Among authors: chezal jm. J Org Chem. 2008 Aug 1;73(15):5989-92. doi: 10.1021/jo800700b. Epub 2008 Jul 3. J Org Chem. 2008. PMID: 18597528
Design, synthesis and preliminary biological evaluation of acridine compounds as potential agents for a combined targeted chemo-radionuclide therapy approach to melanoma.
Desbois N, Gardette M, Papon J, Labarre P, Maisonial A, Auzeloux P, Lartigue C, Bouchon B, Debiton E, Blache Y, Chavignon O, Teulade JC, Maublant J, Madelmont JC, Moins N, Chezal JM. Desbois N, et al. Among authors: chezal jm. Bioorg Med Chem. 2008 Aug 15;16(16):7671-90. doi: 10.1016/j.bmc.2008.07.015. Epub 2008 Jul 10. Bioorg Med Chem. 2008. PMID: 18656367
92 results