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Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models.
Weaver RJ, Blomme EA, Chadwick AE, Copple IM, Gerets HHJ, Goldring CE, Guillouzo A, Hewitt PG, Ingelman-Sundberg M, Jensen KG, Juhila S, Klingmüller U, Labbe G, Liguori MJ, Lovatt CA, Morgan P, Naisbitt DJ, Pieters RHH, Snoeys J, van de Water B, Williams DP, Park BK. Weaver RJ, et al. Among authors: chadwick ae. Nat Rev Drug Discov. 2020 Feb;19(2):131-148. doi: 10.1038/s41573-019-0048-x. Epub 2019 Nov 20. Nat Rev Drug Discov. 2020. PMID: 31748707 Free article. Review.
The mitochondrial paradox.
Penman SL, Jensen RL, Kiy RT, Chadwick AE. Penman SL, et al. Among authors: chadwick ae. Elife. 2020 Jun 25;9:e59140. doi: 10.7554/eLife.59140. Elife. 2020. PMID: 32583799 Free PMC article.
Safety perspectives on presently considered drugs for the treatment of COVID-19.
Penman SL, Kiy RT, Jensen RL, Beoku-Betts C, Alfirevic A, Back D, Khoo SH, Owen A, Pirmohamed M, Park BK, Meng X, Goldring CE, Chadwick AE. Penman SL, et al. Among authors: chadwick ae. Br J Pharmacol. 2020 Oct;177(19):4353-4374. doi: 10.1111/bph.15204. Epub 2020 Aug 13. Br J Pharmacol. 2020. PMID: 32681537 Free PMC article. Review.
The utility of a differentiated preclinical liver model, HepaRG cells, in investigating delayed toxicity via inhibition of mitochondrial-replication induced by fialuridine.
Jolly CE, Douglas O, Kamalian L, Jenkins RE, Beckett AJ, Penman SL, Williams DP, Monshouwer M, Simic D, Snoeys J, Park BK, Chadwick AE. Jolly CE, et al. Among authors: chadwick ae. Toxicol Appl Pharmacol. 2020 Sep 15;403:115163. doi: 10.1016/j.taap.2020.115163. Epub 2020 Jul 28. Toxicol Appl Pharmacol. 2020. PMID: 32730777 Free PMC article.
65 results