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Elevated Hedgehog activity contributes to attenuated DNA damage responses in aged hematopoietic cells.
Scheffold A, Baig AH, Chen Z, von Löhneysen SE, Becker F, Morita Y, Avila AI, Groth M, Lechel A, Schmid F, Kraus JM, Kestler HA, Stilgenbauer S, Philipp M, Burkhalter MD. Scheffold A, et al. Among authors: burkhalter md. Leukemia. 2020 Apr;34(4):1125-1134. doi: 10.1038/s41375-019-0641-3. Epub 2019 Nov 14. Leukemia. 2020. PMID: 31728056 Free PMC article.
Puma and p21 represent cooperating checkpoints limiting self-renewal and chromosomal instability of somatic stem cells in response to telomere dysfunction.
Sperka T, Song Z, Morita Y, Nalapareddy K, Guachalla LM, Lechel A, Begus-Nahrmann Y, Burkhalter MD, Mach M, Schlaudraff F, Liss B, Ju Z, Speicher MR, Rudolph KL. Sperka T, et al. Among authors: burkhalter md. Nat Cell Biol. 2011 Dec 4;14(1):73-9. doi: 10.1038/ncb2388. Nat Cell Biol. 2011. PMID: 22138576
Lin28a--boost your energy for youthful regeneration.
Burkhalter MD, Morita Y, Rudolph KL. Burkhalter MD, et al. EMBO J. 2014 Jan 7;33(1):5-6. doi: 10.1002/embj.201387363. Epub 2013 Dec 19. EMBO J. 2014. PMID: 24357531 Free PMC article.
Resting cells rely on the DNA helicase component MCM2 to build cilia.
Casar Tena T, Maerz LD, Szafranski K, Groth M, Blätte TJ, Donow C, Matysik S, Walther P, Jeggo PA, Burkhalter MD, Philipp M. Casar Tena T, et al. Among authors: burkhalter md. Nucleic Acids Res. 2019 Jan 10;47(1):134-151. doi: 10.1093/nar/gky945. Nucleic Acids Res. 2019. PMID: 30329080 Free PMC article.
30 results