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Removal of senescent cells reduces the viral load and attenuates pulmonary and systemic inflammation in SARS-CoV-2-infected, aged hamsters.
Delval L, Hantute-Ghesquier A, Sencio V, Flaman JM, Robil C, Angulo FS, Lipskaia L, Çobanoğlu O, Lacoste AS, Machelart A, Danneels A, Corbin M, Deruyter L, Heumel S, Idziorek T, Séron K, Sauve F, Bongiovanni A, Prévot V, Wolowczuk I, Belouzard S, Saliou JM, Gosset P, Bernard D, Rouillé Y, Adnot S, Duterque-Coquillaud M, Trottein F. Delval L, et al. Among authors: bernard d. Nat Aging. 2023 Jul;3(7):829-845. doi: 10.1038/s43587-023-00442-w. Epub 2023 Jul 6. Nat Aging. 2023. PMID: 37414987 Free PMC article.
mTOR pathway activation drives lung cell senescence and emphysema.
Houssaini A, Breau M, Kebe K, Abid S, Marcos E, Lipskaia L, Rideau D, Parpaleix A, Huang J, Amsellem V, Vienney N, Validire P, Maitre B, Attwe A, Lukas C, Vindrieux D, Boczkowski J, Derumeaux G, Pende M, Bernard D, Meiners S, Adnot S. Houssaini A, et al. Among authors: bernard d. JCI Insight. 2018 Feb 8;3(3):e93203. doi: 10.1172/jci.insight.93203. eCollection 2018 Feb 8. JCI Insight. 2018. PMID: 29415880 Free PMC article.
The STATus of STAT3 in Lung Cell Senescence?
Adnot S, Lipskaia L, Bernard D. Adnot S, et al. Among authors: bernard d. Am J Respir Cell Mol Biol. 2019 Jul;61(1):5-6. doi: 10.1165/rcmb.2019-0013ED. Am J Respir Cell Mol Biol. 2019. PMID: 30673511 Free PMC article. No abstract available.
The antioxidant N-acetylcysteine protects from lung emphysema but induces lung adenocarcinoma in mice.
Breau M, Houssaini A, Lipskaia L, Abid S, Born E, Marcos E, Czibik G, Attwe A, Beaulieu D, Palazzo A, Flaman JM, Bourachot B, Collin G, Tran Van Nhieu J, Bernard D, Mechta-Grigoriou F, Adnot S. Breau M, et al. Among authors: bernard d. JCI Insight. 2019 Oct 3;4(19):e127647. doi: 10.1172/jci.insight.127647. JCI Insight. 2019. PMID: 31578304 Free PMC article.
Phospholipase A2 receptor 1 promotes lung cell senescence and emphysema in obstructive lung disease.
Beaulieu D, Attwe A, Breau M, Lipskaia L, Marcos E, Born E, Huang J, Abid S, Derumeaux G, Houssaini A, Maitre B, Lefevre M, Vienney N, Bertolino P, Jaber S, Noureddine H, Goehrig D, Vindrieux D, Bernard D, Adnot S. Beaulieu D, et al. Among authors: bernard d. Eur Respir J. 2021 Aug 12;58(2):2000752. doi: 10.1183/13993003.00752-2020. Print 2021 Aug. Eur Respir J. 2021. PMID: 33509955 Free article.
Evidence That SARS-CoV-2 Induces Lung Cell Senescence: Potential Impact on COVID-19 Lung Disease.
Lipskaia L, Maisonnasse P, Fouillade C, Sencio V, Pascal Q, Flaman JM, Born E, Londono-Vallejo A, Le Grand R, Bernard D, Trottein F, Adnot S. Lipskaia L, et al. Among authors: bernard d. Am J Respir Cell Mol Biol. 2022 Jan;66(1):107-111. doi: 10.1165/rcmb.2021-0205LE. Am J Respir Cell Mol Biol. 2022. PMID: 34648725 Free PMC article. No abstract available.
NF-κB-dependent secretome of senescent cells can trigger neuroendocrine transdifferentiation of breast cancer cells.
Raynard C, Ma X, Huna A, Tessier N, Massemin A, Zhu K, Flaman JM, Moulin F, Goehrig D, Medard JJ, Vindrieux D, Treilleux I, Hernandez-Vargas H, Ducreux S, Martin N, Bernard D. Raynard C, et al. Among authors: bernard d. Aging Cell. 2022 Jul;21(7):e13632. doi: 10.1111/acel.13632. Epub 2022 Jun 2. Aging Cell. 2022. PMID: 35653631 Free PMC article.
1,117 results