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Alpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimics.
Balzarini J, Das K, Bernatchez JA, Martinez SE, Ngure M, Keane S, Ford A, Maguire N, Mullins N, John J, Kim Y, Dehaen W, Vande Voorde J, Liekens S, Naesens L, Götte M, Maguire AR, Arnold E. Balzarini J, et al. Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3475-80. doi: 10.1073/pnas.1420233112. Epub 2015 Mar 2. Proc Natl Acad Sci U S A. 2015. PMID: 25733891 Free PMC article.
Guanine α-carboxy nucleoside phosphonate (G-α-CNP) shows a different inhibitory kinetic profile against the DNA polymerases of human immunodeficiency virus (HIV) and herpes viruses.
Balzarini J, Menni M, Das K, van Berckelaer L, Ford A, Maguire NM, Liekens S, Boehmer PE, Arnold E, Götte M, Maguire AR. Balzarini J, et al. Biochem Pharmacol. 2017 Jul 15;136:51-61. doi: 10.1016/j.bcp.2017.04.001. Epub 2017 Apr 6. Biochem Pharmacol. 2017. PMID: 28390939 Free PMC article.
Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket.
Das K, Bauman JD, Rim AS, Dharia C, Clark AD Jr, Camarasa MJ, Balzarini J, Arnold E. Das K, et al. Among authors: balzarini j. J Med Chem. 2011 Apr 28;54(8):2727-37. doi: 10.1021/jm101536x. Epub 2011 Mar 29. J Med Chem. 2011. PMID: 21446702 Free PMC article.
Design and synthesis of α-carboxy phosphononucleosides.
Debarge S, Balzarini J, Maguire AR. Debarge S, et al. Among authors: balzarini j. J Org Chem. 2011 Jan 7;76(1):105-26. doi: 10.1021/jo101738e. Epub 2010 Dec 1. J Org Chem. 2011. PMID: 21121618 Free article.
1,242 results