Arkin MR - Search Results

1

Voreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase II.

Hawtin RE, Stockett DE, Byl JA, McDowell RS, Nguyen T, Arkin MR, Conroy A, Yang W, Osheroff N, Fox JA. Hawtin RE, et al. Among authors: arkin mr. PLoS One. 2010 Apr 15;5(4):e10186. doi: 10.1371/journal.pone.0010186. PLoS One. 2010. PMID: 20419121 Free PMC article.

2

The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions.

Braxton JR, Altobelli CR, Tucker MR, Tse E, Thwin AC, Arkin MR, Southworth DR. Braxton JR, et al. Among authors: arkin mr. Nat Struct Mol Biol. 2023 Dec;30(12):2009-2019. doi: 10.1038/s41594-023-01126-0. Epub 2023 Nov 9. Nat Struct Mol Biol. 2023. PMID: 37945741 Free PMC article.

3

Binding of small molecules to an adaptive protein-protein interface.

Arkin MR, Randal M, DeLano WL, Hyde J, Luong TN, Oslob JD, Raphael DR, Taylor L, Wang J, McDowell RS, Wells JA, Braisted AC. Arkin MR, et al. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1603-8. doi: 10.1073/pnas.252756299. Epub 2003 Feb 11. Proc Natl Acad Sci U S A. 2003. PMID: 12582206 Free PMC article.

4

Discovery of a potent small molecule IL-2 inhibitor through fragment assembly.

Braisted AC, Oslob JD, Delano WL, Hyde J, McDowell RS, Waal N, Yu C, Arkin MR, Raimundo BC. Braisted AC, et al. Among authors: arkin mr. J Am Chem Soc. 2003 Apr 2;125(13):3714-5. doi: 10.1021/ja034247i. J Am Chem Soc. 2003. PMID: 12656598

5

Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.

Raimundo BC, Oslob JD, Braisted AC, Hyde J, McDowell RS, Randal M, Waal ND, Wilkinson J, Yu CH, Arkin MR. Raimundo BC, et al. Among authors: arkin mr. J Med Chem. 2004 Jun 3;47(12):3111-30. doi: 10.1021/jm049967u. J Med Chem. 2004. PMID: 15163192

6

Identification of nonpeptidic small-molecule inhibitors of interleukin-2.

Waal ND, Yang W, Oslob JD, Arkin MR, Hyde J, Lu W, McDowell RS, Yu CH, Raimundo BC. Waal ND, et al. Among authors: arkin mr. Bioorg Med Chem Lett. 2005 Feb 15;15(4):983-7. doi: 10.1016/j.bmcl.2004.12.045. Bioorg Med Chem Lett. 2005. PMID: 15686897

7

A diaminocyclohexyl analog of SNS-032 with improved permeability and bioavailability properties.

Choong IC, Serafimova I, Fan J, Stockett D, Chan E, Cheeti S, Lu Y, Fahr B, Pham P, Arkin MR, Walker DH, Hoch U. Choong IC, et al. Among authors: arkin mr. Bioorg Med Chem Lett. 2008 Nov 1;18(21):5763-5. doi: 10.1016/j.bmcl.2008.09.073. Epub 2008 Sep 24. Bioorg Med Chem Lett. 2008. PMID: 18842409

8

SNS-032 is a potent and selective CDK 2, 7 and 9 inhibitor that drives target modulation in patient samples.

Conroy A, Stockett DE, Walker D, Arkin MR, Hoch U, Fox JA, Hawtin RE. Conroy A, et al. Among authors: arkin mr. Cancer Chemother Pharmacol. 2009 Sep;64(4):723-32. doi: 10.1007/s00280-008-0921-5. Epub 2009 Jan 24. Cancer Chemother Pharmacol. 2009. PMID: 19169685 Clinical Trial.

9

Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6.

Heise CE, Murray J, Augustyn KE, Bravo B, Chugha P, Cohen F, Giannetti AM, Gibbons P, Hannoush RN, Hearn BR, Jaishankar P, Ly CQ, Shah K, Stanger K, Steffek M, Tang Y, Zhao X, Lewcock JW, Renslo AR, Flygare J, Arkin MR. Heise CE, et al. Among authors: arkin mr. PLoS One. 2012;7(12):e50864. doi: 10.1371/journal.pone.0050864. Epub 2012 Dec 5. PLoS One. 2012. PMID: 23227217 Free PMC article.

10

Protein-protein interactions and cancer: small molecules going in for the kill.

Arkin M. Arkin M. Curr Opin Chem Biol. 2005 Jun;9(3):317-24. doi: 10.1016/j.cbpa.2005.03.001. Curr Opin Chem Biol. 2005. PMID: 15939335 Review.

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