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Frentizole derivatives with mTOR inhibiting and senomorphic properties.
Chrienova Z, Rysanek D, Novak J, Vasicova P, Oleksak P, Andrys R, Skarka A, Dumanovic J, Milovanovic Z, Jacevic V, Chvojkova M, Holubova K, Vales K, Skoupilova V, Valko M, Jomova K, Alomar SY, Botelho FD, Franca TCC, Kuca K, Hodny Z, Nepovimova E. Chrienova Z, et al. Among authors: andrys r. Biomed Pharmacother. 2023 Nov;167:115600. doi: 10.1016/j.biopha.2023.115600. Epub 2023 Sep 30. Biomed Pharmacother. 2023. PMID: 37783152 Free article.
Pyridinium Oximes with Ortho-Positioned Chlorine Moiety Exhibit Improved Physicochemical Properties and Efficient Reactivation of Human Acetylcholinesterase Inhibited by Several Nerve Agents.
Zorbaz T, Malinak D, Maraković N, Maček Hrvat N, Zandona A, Novotny M, Skarka A, Andrys R, Benkova M, Soukup O, Katalinić M, Kuca K, Kovarik Z, Musilek K. Zorbaz T, et al. Among authors: andrys r. J Med Chem. 2018 Dec 13;61(23):10753-10766. doi: 10.1021/acs.jmedchem.8b01398. Epub 2018 Nov 20. J Med Chem. 2018. PMID: 30383374
2-Propargylamino-naphthoquinone derivatives as multipotent agents for the treatment of Alzheimer's disease.
Mezeiova E, Janockova J, Andrys R, Soukup O, Kobrlova T, Muckova L, Pejchal J, Simunkova M, Handl J, Micankova P, Capek J, Rousar T, Hrabinova M, Nepovimova E, Marco-Contelles JL, Valko M, Korabecny J. Mezeiova E, et al. Among authors: andrys r. Eur J Med Chem. 2021 Feb 5;211:113112. doi: 10.1016/j.ejmech.2020.113112. Epub 2020 Dec 18. Eur J Med Chem. 2021. PMID: 33360800
Design, synthesis, and in vitro evaluation of BP-1-102 analogs with modified hydrophobic fragments for STAT3 inhibition.
Oleksak P, Psotka M, Vancurova M, Sapega O, Bieblova J, Reinis M, Rysanek D, Mikyskova R, Chalupova K, Malinak D, Svobodova J, Andrys R, Rehulkova H, Skopek V, Ngoc Lam P, Bartek J, Hodny Z, Musilek K. Oleksak P, et al. Among authors: andrys r. J Enzyme Inhib Med Chem. 2021 Dec;36(1):410-424. doi: 10.1080/14756366.2020.1871336. J Enzyme Inhib Med Chem. 2021. PMID: 33440995 Free PMC article.
Privileged multi-target directed propargyl-tacrines combining cholinesterase and monoamine oxidase inhibition activities.
Chrienova Z, Nepovimova E, Andrys R, Dolezal R, Janockova J, Muckova L, Fabova L, Soukup O, Oleksak P, Valis M, Korabecny J, Marco-Contelles J, Kuca K. Chrienova Z, et al. Among authors: andrys r. J Enzyme Inhib Med Chem. 2022 Dec;37(1):2605-2620. doi: 10.1080/14756366.2022.2122054. J Enzyme Inhib Med Chem. 2022. PMID: 36131624 Free PMC article.
Discovery of small molecule mechanistic target of rapamycin inhibitors as anti-aging and anti-cancer therapeutics.
Chrienova Z, Rysanek D, Oleksak P, Stary D, Bajda M, Reinis M, Mikyskova R, Novotny O, Andrys R, Skarka A, Vasicova P, Novak J, Valis M, Kuca K, Hodny Z, Nepovimova E. Chrienova Z, et al. Among authors: andrys r. Front Aging Neurosci. 2022 Dec 6;14:1048260. doi: 10.3389/fnagi.2022.1048260. eCollection 2022. Front Aging Neurosci. 2022. PMID: 36561137 Free PMC article.
Development of submicromolar 17β-HSD10 inhibitors and their in vitro and in vivo evaluation.
Benek O, Vaskova M, Miskerikova M, Schmidt M, Andrys R, Rotterova A, Skarka A, Hatlapatkova J, Karasova JZ, Medvecky M, Hroch L, Vinklarova L, Fisar Z, Hroudova J, Handl J, Capek J, Rousar T, Kobrlova T, Dolezal R, Soukup O, Aitken L, Gunn-Moore F, Musilek K. Benek O, et al. Among authors: andrys r. Eur J Med Chem. 2023 Oct 5;258:115593. doi: 10.1016/j.ejmech.2023.115593. Epub 2023 Jun 24. Eur J Med Chem. 2023. PMID: 37390508
BODIPY-labelled acetylcholinesterase reactivators can be encapsulated into ferritin nanovehicles for enhanced bioavailability in the CNS.
Prchalova E, Sukupova M, Malinak D, Andrys R, Sivak L, Pekarik V, Skarka A, Svobodova J, Prchal L, Fresser L, Heger Z, Musilek K. Prchalova E, et al. Among authors: andrys r. Biomed Pharmacother. 2023 Nov;167:115490. doi: 10.1016/j.biopha.2023.115490. Epub 2023 Sep 16. Biomed Pharmacother. 2023. PMID: 37722189 Free article.
41 results