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Conformational regulation of CRISPR-associated nucleases.
Jackson RN, van Erp PB, Sternberg SH, Wiedenheft B. Jackson RN, et al. Curr Opin Microbiol. 2017 Jun;37:110-119. doi: 10.1016/j.mib.2017.05.010. Epub 2017 Jun 21. Curr Opin Microbiol. 2017. PMID: 28646675 Free PMC article. Review.
CRISPR RNA-guided autonomous delivery of Cas9.
Wilkinson RA, Martin C, Nemudryi AA, Wiedenheft B. Wilkinson RA, et al. Nat Struct Mol Biol. 2019 Jan;26(1):14-24. doi: 10.1038/s41594-018-0173-y. Epub 2018 Dec 31. Nat Struct Mol Biol. 2019. PMID: 30598555 Free PMC article. Review.
Cas1 and the Csy complex are opposing regulators of Cas2/3 nuclease activity.
Rollins MF, Chowdhury S, Carter J, Golden SM, Wilkinson RA, Bondy-Denomy J, Lander GC, Wiedenheft B. Rollins MF, et al. Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):E5113-E5121. doi: 10.1073/pnas.1616395114. Epub 2017 Apr 24. Proc Natl Acad Sci U S A. 2017. PMID: 28438998 Free PMC article.
Multiple mechanisms for CRISPR-Cas inhibition by anti-CRISPR proteins.
Bondy-Denomy J, Garcia B, Strum S, Du M, Rollins MF, Hidalgo-Reyes Y, Wiedenheft B, Maxwell KL, Davidson AR. Bondy-Denomy J, et al. Nature. 2015 Oct 1;526(7571):136-9. doi: 10.1038/nature15254. Epub 2015 Sep 23. Nature. 2015. PMID: 26416740 Free PMC article.
13 results