R01 GM104366/GM/NIGMS NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2014	1
2015	4
2016	3
2017	2
2018	1
2019	1
2020	3
2021	2
2022	1
2024	0

1

Santos WL, Lynch KR. Santos WL, et al. ACS Chem Biol. 2015 Jan 16;10(1):225-33. doi: 10.1021/cb5008426. Epub 2014 Nov 19. ACS Chem Biol. 2015. PMID: 25384187 Free PMC article. Review.

2

Sphingosine kinase inhibitors: a review of patent literature (2006-2015).

Lynch KR, Thorpe SB, Santos WL. Lynch KR, et al. Expert Opin Ther Pat. 2016 Dec;26(12):1409-1416. doi: 10.1080/13543776.2016.1226282. Epub 2016 Aug 30. Expert Opin Ther Pat. 2016. PMID: 27539678 Free PMC article. Review.

3

Saccharomyces cerevisiae as a platform for assessing sphingolipid lipid kinase inhibitors.

Kharel Y, Agah S, Huang T, Mendelson AJ, Eletu OT, Barkey-Bircann P, Gesualdi J, Smith JS, Santos WL, Lynch KR. Kharel Y, et al. PLoS One. 2018 Apr 19;13(4):e0192179. doi: 10.1371/journal.pone.0192179. eCollection 2018. PLoS One. 2018. PMID: 29672528 Free PMC article.

4

Sphingosine Kinase 2 Deficiency Attenuates Kidney Fibrosis via IFN-γ.

Bajwa A, Huang L, Kurmaeva E, Ye H, Dondeti KR, Chroscicki P, Foley LS, Balogun ZA, Alexander KJ, Park H, Lynch KR, Rosin DL, Okusa MD. Bajwa A, et al. J Am Soc Nephrol. 2017 Apr;28(4):1145-1161. doi: 10.1681/ASN.2016030306. Epub 2016 Oct 31. J Am Soc Nephrol. 2017. PMID: 27799486 Free PMC article.

5

Probing the substitution pattern of indole-based scaffold reveals potent and selective sphingosine kinase 2 inhibitors.

Congdon M, Fritzemeier RG, Kharel Y, Brown AM, Serbulea V, Bevan DR, Lynch KR, Santos WL. Congdon M, et al. Eur J Med Chem. 2021 Feb 15;212:113121. doi: 10.1016/j.ejmech.2020.113121. Epub 2020 Dec 29. Eur J Med Chem. 2021. PMID: 33445156 Free PMC article.

6

Discovery of a Small Side Cavity in Sphingosine Kinase 2 that Enhances Inhibitor Potency and Selectivity.

Sibley CD, Morris EA, Kharel Y, Brown AM, Huang T, Bevan DR, Lynch KR, Santos WL. Sibley CD, et al. J Med Chem. 2020 Feb 13;63(3):1178-1198. doi: 10.1021/acs.jmedchem.9b01508. Epub 2020 Jan 28. J Med Chem. 2020. PMID: 31895563 Free PMC article.

7

Sphingosine Kinase 2 Inhibitors: Rigid Aliphatic Tail Derivatives Deliver Potent and Selective Analogues.

Pashikanti S, Foster DJ, Kharel Y, Brown AM, Bevan DR, Lynch KR, Santos WL. Pashikanti S, et al. ACS Bio Med Chem Au. 2022 Oct 19;2(5):469-489. doi: 10.1021/acsbiomedchemau.2c00017. Epub 2022 Jun 29. ACS Bio Med Chem Au. 2022. PMID: 36281302 Free PMC article.

8

Lipophilic tail modifications of 2-(hydroxymethyl)pyrrolidine scaffold reveal dual sphingosine kinase 1 and 2 inhibitors.

Li H, Sibley CD, Kharel Y, Huang T, Brown AM, Wonilowicz LG, Bevan DR, Lynch KR, Santos WL. Li H, et al. Bioorg Med Chem. 2021 Jan 15;30:115941. doi: 10.1016/j.bmc.2020.115941. Epub 2020 Dec 13. Bioorg Med Chem. 2021. PMID: 33385956 Free PMC article.

9

Structure-activity relationship studies of the lipophilic tail region of sphingosine kinase 2 inhibitors.

Congdon MD, Childress ES, Patwardhan NN, Gumkowski J, Morris EA, Kharel Y, Lynch KR, Santos WL. Congdon MD, et al. Bioorg Med Chem Lett. 2015 Nov 1;25(21):4956-4960. doi: 10.1016/j.bmcl.2015.03.041. Epub 2015 Mar 23. Bioorg Med Chem Lett. 2015. PMID: 25862200 Free PMC article.

10

In Silico Characterization of Structural Distinctions between Isoforms of Human and Mouse Sphingosine Kinases for Accelerating Drug Discovery.

Worrell BL, Brown AM, Santos WL, Bevan DR. Worrell BL, et al. J Chem Inf Model. 2019 May 28;59(5):2339-2351. doi: 10.1021/acs.jcim.8b00931. Epub 2019 Mar 19. J Chem Inf Model. 2019. PMID: 30844267 Free PMC article.

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