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21 results

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Page 1
Making the invisible enemy visible.
Croll TI, Diederichs K, Fischer F, Fyfe CD, Gao Y, Horrell S, Joseph AP, Kandler L, Kippes O, Kirsten F, Müller K, Nolte K, Payne AM, Reeves M, Richardson JS, Santoni G, Stäb S, Tronrud DE, von Soosten LC, Williams CJ, Thorn A. Croll TI, et al. Nat Struct Mol Biol. 2021 May;28(5):404-408. doi: 10.1038/s41594-021-00593-7. Nat Struct Mol Biol. 2021. PMID: 33972785 Free PMC article.
However, the macromolecular structures of SARS-CoV-2 proteins that were solved with great speed and urgency can contain errors that may hinder drug design. ...
However, the macromolecular structures of SARS-CoV-2 proteins that were solved with great speed and urgency can contain errors that m …
Making the invisible enemy visible.
Croll T, Diederichs K, Fischer F, Fyfe C, Gao Y, Horrell S, Joseph AP, Kandler L, Kippes O, Kirsten F, Müller K, Nolte K, Payne A, Reeves MG, Richardson J, Santoni G, Stäb S, Tronrud D, von Soosten L, Williams C, Thorn A. Croll T, et al. bioRxiv [Preprint]. 2020 Dec 28:2020.10.07.307546. doi: 10.1101/2020.10.07.307546. bioRxiv. 2020. PMID: 33052340 Free PMC article. Updated. Preprint.
During the COVID-19 pandemic, structural biologists rushed to solve the structures of the 28 proteins encoded by the SARS-CoV-2 genome in order to understand the viral life cycle and enable structure-based drug design. In addition to the 204 previously solved struct …
During the COVID-19 pandemic, structural biologists rushed to solve the structures of the 28 proteins encoded by the SARS-CoV-2 genom …
Structural Basis for Expansion of the Genetic Alphabet with an Artificial Nucleobase Pair.
Betz K, Kimoto M, Diederichs K, Hirao I, Marx A. Betz K, et al. Angew Chem Int Ed Engl. 2017 Sep 18;56(39):12000-12003. doi: 10.1002/anie.201704190. Epub 2017 Jun 27. Angew Chem Int Ed Engl. 2017. PMID: 28594080
Here, we report structural insight into the insertion of one of the most promising hydrophobic unnatural base pairs, the dDs-dPx pair, into a DNA strand by a DNA polymerase. We solved a crystal structure of KlenTaq DNA polymerase with a modified template/primer duplex boun …
Here, we report structural insight into the insertion of one of the most promising hydrophobic unnatural base pairs, the dDs-dPx pair, into …
Making a difference in multi-data-set crystallography: simple and deterministic data-scaling/selection methods.
Assmann GM, Wang M, Diederichs K. Assmann GM, et al. Acta Crystallogr D Struct Biol. 2020 Jul 1;76(Pt 7):636-652. doi: 10.1107/S2059798320006348. Epub 2020 Jun 17. Acta Crystallogr D Struct Biol. 2020. PMID: 32627737 Free PMC article.
To explore the limits, the procedure was tested with much fewer data than originally required and could still solve the structure in several cases. In addition, an SSX data challenge, minimizing the number of (simulated) data sets necessary to solve the structure, w …
To explore the limits, the procedure was tested with much fewer data than originally required and could still solve the structure in …
Structures of KOD and 9°N DNA polymerases complexed with primer template duplex.
Bergen K, Betz K, Welte W, Diederichs K, Marx A. Bergen K, et al. Chembiochem. 2013 Jun 17;14(9):1058-62. doi: 10.1002/cbic.201300175. Epub 2013 Jun 3. Chembiochem. 2013. PMID: 23733496
Replicate it: Structures of KOD and 9N DNA polymerases, two enzymes that are widely used to replicate DNA with highly modified nucleotides, were solved at high resolution in complex with primer/template duplex. ...
Replicate it: Structures of KOD and 9N DNA polymerases, two enzymes that are widely used to replicate DNA with highly modified nucleotides, …
Crystallization and preliminary analysis of the NqrA and NqrC subunits of the Na+-translocating NADH:ubiquinone oxidoreductase from Vibrio cholerae.
Vohl G, Nedielkov R, Claussen B, Casutt MS, Vorburger T, Diederichs K, Möller HM, Steuber J, Fritz G. Vohl G, et al. Acta Crystallogr F Struct Biol Commun. 2014 Jul;70(Pt 7):987-92. doi: 10.1107/S2053230X14009881. Epub 2014 Jun 19. Acta Crystallogr F Struct Biol Commun. 2014. PMID: 25005105 Free PMC article.
The major domains of the NqrA and NqrC subunits were heterologously expressed in Escherichia coli and crystallized. The structure of NqrA1-377 was solved in space groups C2221 and P21 by SAD phasing and molecular replacement at 1.9 and 2.1 A resolution, respectively. ...
The major domains of the NqrA and NqrC subunits were heterologously expressed in Escherichia coli and crystallized. The structure of NqrA1-3 …
Crystal structure of human beta2-glycoprotein I: implications for phospholipid binding and the antiphospholipid syndrome.
Schwarzenbacher R, Zeth K, Diederichs K, Gries A, Kostner GM, Laggner P, Prassl R. Schwarzenbacher R, et al. EMBO J. 1999 Nov 15;18(22):6228-39. doi: 10.1093/emboj/18.22.6228. EMBO J. 1999. PMID: 10562535 Free PMC article.
The high affinity of human plasma beta2-glycoprotein I (beta(2)GPI), also known as apolipoprotein-H (ApoH), for negatively charged phospholipids determines its implication in a variety of physiological pathways, including blood coagulation and the immune response. beta(2)GPI is c …
The high affinity of human plasma beta2-glycoprotein I (beta(2)GPI), also known as apolipoprotein-H (ApoH), for negatively charged phospholi …
Crystallization of a 45 kDa peroxygenase/peroxidase from the mushroom Agrocybe aegerita and structure determination by SAD utilizing only the haem iron.
Piontek K, Ullrich R, Liers C, Diederichs K, Plattner DA, Hofrichter M. Piontek K, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Jun 1;66(Pt 6):693-8. doi: 10.1107/S1744309110013515. Epub 2010 May 27. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010. PMID: 20516602 Free PMC article.
One crystal form containing two molecules per asymmetric unit was solved at 2.2 A resolution by SAD using the anomalous signal of the haem iron. ...
One crystal form containing two molecules per asymmetric unit was solved at 2.2 A resolution by SAD using the anomalous signal of the …
Yeast D-amino acid oxidase: structural basis of its catalytic properties.
Pollegioni L, Diederichs K, Molla G, Umhau S, Welte W, Ghisla S, Pilone MS. Pollegioni L, et al. J Mol Biol. 2002 Nov 29;324(3):535-46. doi: 10.1016/s0022-2836(02)01062-8. J Mol Biol. 2002. PMID: 12445787
The 3D structure of the flavoprotein D-amino acid oxidase (DAAO) from the yeast Rhodotorula gracilis (RgDAAO) in complex with the competitive inhibitor anthranilate was solved (resolution 1.9A) and structural features relevant for the overall conformation and for catalytic …
The 3D structure of the flavoprotein D-amino acid oxidase (DAAO) from the yeast Rhodotorula gracilis (RgDAAO) in complex with the competitiv …
21 results