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MicroRNA.
Lu TX, Rothenberg ME. Lu TX, et al. J Allergy Clin Immunol. 2018 Apr;141(4):1202-1207. doi: 10.1016/j.jaci.2017.08.034. Epub 2017 Oct 23. J Allergy Clin Immunol. 2018. PMID: 29074454 Free PMC article. Review.
MicroRNAs (miRNAs) are small endogenous RNAs that regulate gene-expression posttranscriptionally. ...MiRNA mimics and miRNA inhibitors currently in preclinical development have shown promise as novel therapeutic agents. ...
MicroRNAs (miRNAs) are small endogenous RNAs that regulate gene-expression posttranscriptionally. ...MiRNA mimics …
The guideline of the design and validation of MiRNA mimics.
Wang Z. Wang Z. Methods Mol Biol. 2011;676:211-23. doi: 10.1007/978-1-60761-863-8_15. Methods Mol Biol. 2011. PMID: 20931400
The miRNA mimic technology (miR-Mimic) is an innovative approach for gene silencing. ...Unlike endogenous miRNAs, miR-Mimics act in a gene-specific fashion. The miR-Mimic approach belongs to the "miRNA-targeting" and "miRNA- …
The miRNA mimic technology (miR-Mimic) is an innovative approach for gene silencing. ...Unlike endogenous miRNAs …
MicroRNA therapeutics: towards a new era for the management of cancer and other diseases.
Rupaimoole R, Slack FJ. Rupaimoole R, et al. Nat Rev Drug Discov. 2017 Mar;16(3):203-222. doi: 10.1038/nrd.2016.246. Epub 2017 Feb 17. Nat Rev Drug Discov. 2017. PMID: 28209991 Review.
In just over two decades since the discovery of the first microRNA (miRNA), the field of miRNA biology has expanded considerably. Insights into the roles of miRNAs in development and disease, particularly in cancer, have made miRNAs attractive tools an …
In just over two decades since the discovery of the first microRNA (miRNA), the field of miRNA biology has expanded considerab …
Accelerated wound healing in diabetic mice by miRNA-497 and its anti-inflammatory activity.
Ban E, Jeong S, Park M, Kwon H, Park J, Song EJ, Kim A. Ban E, et al. Biomed Pharmacother. 2020 Jan;121:109613. doi: 10.1016/j.biopha.2019.109613. Epub 2019 Nov 7. Biomed Pharmacother. 2020. PMID: 31707336 Free article.
Diabetic foot ulcers represent one of the major and rising health issues, as the number of diabetic patients is increasing. MicroRNAs (miRNAs) are among various bioactive molecules under investigation for diabetic wound healing. ...The therapeutic potential of mi …
Diabetic foot ulcers represent one of the major and rising health issues, as the number of diabetic patients is increasing. MicroRNAs …
Viral miRNA regulation of host gene expression.
Diggins NL, Hancock MH. Diggins NL, et al. Semin Cell Dev Biol. 2023 Sep 15;146:2-19. doi: 10.1016/j.semcdb.2022.11.007. Epub 2022 Nov 30. Semin Cell Dev Biol. 2023. PMID: 36463091 Review.
Diverse viruses encode for miRNAs but little sequence homology exists between miRNAs of different viral species. ...We also highlight how viral miRNAs can mimic host cell miRNAs as well as how viral miRNAs have evolved to regulate host …
Diverse viruses encode for miRNAs but little sequence homology exists between miRNAs of different viral species. ...We also hi …
Obesity-associated exosomal miRNAs modulate glucose and lipid metabolism in mice.
Castaño C, Kalko S, Novials A, Párrizas M. Castaño C, et al. Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):12158-12163. doi: 10.1073/pnas.1808855115. Epub 2018 Nov 14. Proc Natl Acad Sci U S A. 2018. PMID: 30429322 Free PMC article.
Moreover, administration of control exosomes transfected with obesity-associated miRNA mimics strongly induces glucose intolerance in lean mice and results in central obesity and hepatic steatosis. Expression of the candidate target gene Ppara is decreased in white …
Moreover, administration of control exosomes transfected with obesity-associated miRNA mimics strongly induces glucose intoler …
Milk exosomes-mediated miR-31-5p delivery accelerates diabetic wound healing through promoting angiogenesis.
Yan C, Chen J, Wang C, Yuan M, Kang Y, Wu Z, Li W, Zhang G, Machens HG, Rinkevich Y, Chen Z, Yang X, Xu X. Yan C, et al. Drug Deliv. 2022 Dec;29(1):214-228. doi: 10.1080/10717544.2021.2023699. Drug Deliv. 2022. PMID: 34985397 Free PMC article.
However, miRNA therapies have limitations due to lacking an effective delivery system. ...Thus, we conceived the idea of exogenously supplementing miR-31-5p mimics to treat the diabetic wound. We used milk-derived exosomes as a novel system for miR-31-5p delivery an …
However, miRNA therapies have limitations due to lacking an effective delivery system. ...Thus, we conceived the idea of exogenously …
MiRNA-Based Therapies for Lung Cancer: Opportunities and Challenges?
Yang H, Liu Y, Chen L, Zhao J, Guo M, Zhao X, Wen Z, He Z, Chen C, Xu L. Yang H, et al. Biomolecules. 2023 May 23;13(6):877. doi: 10.3390/biom13060877. Biomolecules. 2023. PMID: 37371458 Free PMC article. Review.
Despite new advances in immune checkpoint and targeted therapies in recent years, the prognosis for lung cancer patients, especially those in advanced stages, remains poor. MicroRNAs (miRNAs) have been shown to modulate tumor development at multiple levels, and as s …
Despite new advances in immune checkpoint and targeted therapies in recent years, the prognosis for lung cancer patients, especially those i …
MicroRNA in lung cancer: role, mechanisms, pathways and therapeutic relevance.
Iqbal MA, Arora S, Prakasam G, Calin GA, Syed MA. Iqbal MA, et al. Mol Aspects Med. 2019 Dec;70:3-20. doi: 10.1016/j.mam.2018.07.003. Epub 2018 Aug 18. Mol Aspects Med. 2019. PMID: 30102929 Review.
Clinical success of therapies is not very promising due to - late diagnosis, limited therapeutic tools, relapse and the development of drug resistance. Recently, small 20-24 nucleotides molecules called microRNAs (miRNAs) have come into the limelight as they play ou …
Clinical success of therapies is not very promising due to - late diagnosis, limited therapeutic tools, relapse and the development of drug …
Delivery of therapeutic miRNA using polymer-based formulation.
Ban E, Kwon TH, Kim A. Ban E, et al. Drug Deliv Transl Res. 2019 Dec;9(6):1043-1056. doi: 10.1007/s13346-019-00645-y. Drug Deliv Transl Res. 2019. PMID: 31049843 Review.
In particular, non-viral, polymer-based carriers have shown advantages such as versatility of structural modifications and protection of unstable miRNA. Herein, we review properties and applications of poly (lactic-co-glycolic acid), chitosan, polyethyleneimine, and polyam …
In particular, non-viral, polymer-based carriers have shown advantages such as versatility of structural modifications and protection of uns …
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