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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 1
2001 1
2004 1
2006 1
2007 1
2008 1
2012 1
2013 4
2014 2
2015 2
2016 5
2017 2
2018 3
2019 2
2020 2
2021 2
2022 1
2023 1
2024 0

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30 results

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Page 1
De Novo Pathogenic Variants in CACNA1E Cause Developmental and Epileptic Encephalopathy with Contractures, Macrocephaly, and Dyskinesias.
Helbig KL, Lauerer RJ, Bahr JC, Souza IA, Myers CT, Uysal B, Schwarz N, Gandini MA, Huang S, Keren B, Mignot C, Afenjar A, Billette de Villemeur T, Héron D, Nava C, Valence S, Buratti J, Fagerberg CR, Soerensen KP, Kibaek M, Kamsteeg EJ, Koolen DA, Gunning B, Schelhaas HJ, Kruer MC, Fox J, Bakhtiari S, Jarrar R, Padilla-Lopez S, Lindstrom K, Jin SC, Zeng X, Bilguvar K, Papavasileiou A, Xing Q, Zhu C, Boysen K, Vairo F, Lanpher BC, Klee EW, Tillema JM, Payne ET, Cousin MA, Kruisselbrink TM, Wick MJ, Baker J, Haan E, Smith N, Sadeghpour A, Davis EE, Katsanis N; Task Force for Neonatal Genomics; Corbett MA, MacLennan AH, Gecz J, Biskup S, Goldmann E, Rodan LH, Kichula E, Segal E, Jackson KE, Asamoah A, Dimmock D, McCarrier J, Botto LD, Filloux F, Tvrdik T, Cascino GD, Klingerman S, Neumann C, Wang R, Jacobsen JC, Nolan MA, Snell RG, Lehnert K, Sadleir LG, Anderlid BM, Kvarnung M, Guerrini R, Friez MJ, Lyons MJ, Leonhard J, Kringlen G, Casas K, El Achkar CM, Smith LA, Rotenberg A, Poduri A, Sanchis-Juan A, Carss KJ, Rankin J, Zeman A, Raymond FL, Blyth M, Kerr B, Ruiz K, Urquhart J, Hughes I, Banka S; Deciphering Developmental Disorders Study; Hedrich UBS, Scheffer IE, Helbig I, Zampo… See abstract for full author list ➔ Helbig KL, et al. Am J Hum Genet. 2018 Nov 1;103(5):666-678. doi: 10.1016/j.ajhg.2018.09.006. Epub 2018 Oct 18. Am J Hum Genet. 2018. PMID: 30343943 Free PMC article.
Functional analysis of several S6 variants revealed consistent gain-of-function effects comprising facilitated voltage-dependent activation and slowed inactivation. Another variant located in the domain II S4-S5 linker results in facilitated activation and increased curren …
Functional analysis of several S6 variants revealed consistent gain-of-function effects comprising facilitated voltage-dependent activation …
A long-acting C-natriuretic peptide for achondroplasia.
Schneider EL, Carreras CW, Reid R, Ashley GW, Santi DV. Schneider EL, et al. Proc Natl Acad Sci U S A. 2022 Jul 26;119(30):e2201067119. doi: 10.1073/pnas.2201067119. Epub 2022 Jul 18. Proc Natl Acad Sci U S A. 2022. PMID: 35858423 Free PMC article.
We used a technology for half-life extension, whereby a drug is attached to tetra-polyethylene glycol hydrogels (tetra-PEG) by beta-eliminative linkers that cleave at predetermined rates. These hydrogels-fabricated as uniform 60-mum microspheres-are injected subcutaneously …
We used a technology for half-life extension, whereby a drug is attached to tetra-polyethylene glycol hydrogels (tetra-PEG) by beta-eliminat …
A Very Long-acting Exatecan and Its Synergism with DNA Damage Response Inhibitors.
Fontaine SD, Carreras CW, Reid RR, Ashley GW, Santi DV. Fontaine SD, et al. Cancer Res Commun. 2023 May 24;3(5):908-916. doi: 10.1158/2767-9764.CRC-22-0517. eCollection 2023 May. Cancer Res Commun. 2023. PMID: 37377899 Free PMC article.
Exa was conjugated to a 4-arm 40 kDa PEG through a beta-eliminative cleavable linker. Pharmacokinetic studies in mice showed that the conjugate has an apparent circulating half-life of 12 hours, which reflects a composite of both the rate of renal elimination (half-life 18 …
Exa was conjugated to a 4-arm 40 kDa PEG through a beta-eliminative cleavable linker. Pharmacokinetic studies in mice showed that the …
beta-Eliminative releasable linkers adapted for bioconjugation of macromolecules to phenols.
Schneider EL, Robinson L, Reid R, Ashley GW, Santi DV. Schneider EL, et al. Bioconjug Chem. 2013 Dec 18;24(12):1990-7. doi: 10.1021/bc4002882. Epub 2013 Nov 20. Bioconjug Chem. 2013. PMID: 24171387
We recently reported a chemical approach for half-life extension that utilizes sets of releasable linkers to attach drugs to macromolecules via a cleavable carbamate group (Santi et al., Proc. Nat. Acad. Sci. U.S.A. 2012, 109, 6211-6216). The linkers undergo a beta- …
We recently reported a chemical approach for half-life extension that utilizes sets of releasable linkers to attach drugs to macromol …
Attenuation of the Reaction of Michael Acceptors with Biologically Important Nucleophiles.
Hearn BR, Fontaine SD, Schneider EL, Kraemer Y, Ashley GW, Santi DV. Hearn BR, et al. Bioconjug Chem. 2021 Apr 21;32(4):794-800. doi: 10.1021/acs.bioconjchem.1c00075. Epub 2021 Apr 6. Bioconjug Chem. 2021. PMID: 33822591
We also prepared a large series of gamma-gem-dimethyl beta-eliminative linkers and showed excellent structure-activity relationships of elimination rates with corresponding unsubstituted parent linkers. ...Both linkers provided the desired half-life extension …
We also prepared a large series of gamma-gem-dimethyl beta-eliminative linkers and showed excellent structure-activity relationships …
Hydrogel Drug Delivery System Using Self-Cleaving Covalent Linkers for Once-a-Week Administration of Exenatide.
Schneider EL, Henise J, Reid R, Ashley GW, Santi DV. Schneider EL, et al. Bioconjug Chem. 2016 May 18;27(5):1210-5. doi: 10.1021/acs.bioconjchem.5b00690. Epub 2016 Mar 22. Bioconjug Chem. 2016. PMID: 26930186
The peptide was covalently attached to Tetra-PEG hydrogel microspheres by a cleavable beta-eliminative linker; upon s.c. injection, the exenatide is slowly released at a rate dictated by the linker. A second beta-eliminative linker with a slower cleavage rate …
The peptide was covalently attached to Tetra-PEG hydrogel microspheres by a cleavable beta-eliminative linker; upon s.c. injection, t …
Solid-phase synthesis and kinetic characterization of fluorogenic enzyme-degradable hydrogel cross-linkers.
Moss JA, Stokols S, Hixon MS, Ashley FT, Chang JY, Janda KD. Moss JA, et al. Biomacromolecules. 2006 Apr;7(4):1011-6. doi: 10.1021/bm051001s. Biomacromolecules. 2006. PMID: 16602715 Free PMC article.
Of critical importance in drug delivery and tissue engineering applications is the degradability of implanted polymeric materials. The use of peptide-derived cross-linkers in hydrogel design is a valuable approach by which polymeric carriers can be endowed with enzymatic d …
Of critical importance in drug delivery and tissue engineering applications is the degradability of implanted polymeric materials. The use o …
A once-monthly GLP-1 receptor agonist for treatment of diabetic cats.
Schneider EL, Reid R, Parkes DG, Lutz TA, Ashley GW, Santi DV. Schneider EL, et al. Domest Anim Endocrinol. 2020 Jan;70:106373. doi: 10.1016/j.domaniend.2019.07.001. Epub 2019 Jul 8. Domest Anim Endocrinol. 2020. PMID: 31479925
Here, the peptide is covalently attached to hydrogel microspheres by a self-cleaving beta-eliminative linker; after subcutaneous injection of the microspheres, the peptide is slowly released from the depot to the systemic circulation. ...Finally, subcutaneous injection of …
Here, the peptide is covalently attached to hydrogel microspheres by a self-cleaving beta-eliminative linker; after subcutaneous inje …
Surgical sealants with tunable swelling, burst pressures, and biodegradation rates.
Henise J, Hearn BR, Santi DV, Kamata H, Sakai T, Ashley GW. Henise J, et al. J Biomed Mater Res B Appl Biomater. 2017 Aug;105(6):1602-1611. doi: 10.1002/jbm.b.33701. Epub 2016 May 5. J Biomed Mater Res B Appl Biomater. 2017. PMID: 27149244
Variants of each gel-format were prepared that contained a beta-eliminative cleavable linker in the crosslinks to control degradation rate. Linkers of this type self-cleave with half-lives spanning from hours to years, and offer the unique ability to precisely tune …
Variants of each gel-format were prepared that contained a beta-eliminative cleavable linker in the crosslinks to control degradation …
Subcutaneously Administered Self-Cleaving Hydrogel-Octreotide Conjugates Provide Very Long-Acting Octreotide.
Schneider EL, Henise J, Reid R, Ashley GW, Santi DV. Schneider EL, et al. Bioconjug Chem. 2016 Jul 20;27(7):1638-44. doi: 10.1021/acs.bioconjchem.6b00188. Epub 2016 Jun 20. Bioconjug Chem. 2016. PMID: 27253622
To overcome such shortcomings, Tetra-PEG hydrogel microspheres were covalently attached to the alpha-amine of d-Phe(1) or the epsilon-amine of Lys(5) of octreotide by a self-cleaving beta-eliminative linker; upon subcutaneous injection in the rat using a small-bore needle, …
To overcome such shortcomings, Tetra-PEG hydrogel microspheres were covalently attached to the alpha-amine of d-Phe(1) or the epsilon-amine …
30 results