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Page 1
Did you mean zf miu (2 results)?
Proteolysis-targeting chimeras with reduced off-targets.
Nguyen TM, Sreekanth V, Deb A, Kokkonda P, Tiwari PK, Donovan KA, Shoba V, Chaudhary SK, Mercer JAM, Lai S, Sadagopan A, Jan M, Fischer ES, Liu DR, Ebert BL, Choudhary A. Nguyen TM, et al. Nat Chem. 2024 Feb;16(2):218-228. doi: 10.1038/s41557-023-01379-8. Epub 2023 Dec 18. Nat Chem. 2024. PMID: 38110475 Free PMC article.
Here we developed a high-throughput platform that interrogates off-target degradation and found that reported pomalidomide-based PROTACs induce degradation of several ZF proteins. We generated a library of pomalidomide analogues to understand how functionalizing different …
Here we developed a high-throughput platform that interrogates off-target degradation and found that reported pomalidomide-based PROTACs ind …
Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia.
Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y, Ren R, Leung KSM, Lau EHY, Wong JY, Xing X, Xiang N, Wu Y, Li C, Chen Q, Li D, Liu T, Zhao J, Liu M, Tu W, Chen C, Jin L, Yang R, Wang Q, Zhou S, Wang R, Liu H, Luo Y, Liu Y, Shao G, Li H, Tao Z, Yang Y, Deng Z, Liu B, Ma Z, Zhang Y, Shi G, Lam TTY, Wu JT, Gao GF, Cowling BJ, Yang B, Leung GM, Feng Z. Li Q, et al. N Engl J Med. 2020 Mar 26;382(13):1199-1207. doi: 10.1056/NEJMoa2001316. Epub 2020 Jan 29. N Engl J Med. 2020. PMID: 31995857 Free PMC article.
Continuous evolution of compact protein degradation tags regulated by selective molecular glues.
Mercer JAM, DeCarlo SJ, Roy Burman SS, Sreekanth V, Nelson AT, Hunkeler M, Chen PJ, Donovan KA, Kokkonda P, Tiwari PK, Shoba VM, Deb A, Choudhary A, Fischer ES, Liu DR. Mercer JAM, et al. Science. 2024 Mar 15;383(6688):eadk4422. doi: 10.1126/science.adk4422. Epub 2024 Mar 15. Science. 2024. PMID: 38484051
We developed a phage-assisted continuous evolution platform for molecular glue complexes (MG-PACE) and evolved a 36-amino acid zinc finger (ZF) degron (SD40) that binds the ubiquitin ligase substrate receptor cereblon in complex with PT-179, an orthogonal thalidomide deriv …
We developed a phage-assisted continuous evolution platform for molecular glue complexes (MG-PACE) and evolved a 36-amino acid zinc finger ( …
Genome-wide analysis of zinc finger-homeodomain (ZF-HD) transcription factors in diploid and tetraploid cotton.
Xing L, Peng K, Xue S, Yuan W, Zhu B, Zhao P, Wu H, Cheng Y, Fang M, Liu Z. Xing L, et al. Funct Integr Genomics. 2022 Dec;22(6):1269-1281. doi: 10.1007/s10142-022-00913-0. Epub 2022 Nov 12. Funct Integr Genomics. 2022. PMID: 36369302
ZF-HD (zinc finger-homeodomain) gene family plays important roles in plant growth, development, and various stress responses. ...Transcriptome analysis showed that 6 Gossypium hirsutum and 4 Gossypium barbadense ZF-HD genes were expressed in all tested tissues. Furt …
ZF-HD (zinc finger-homeodomain) gene family plays important roles in plant growth, development, and various stress responses. ...Tran …
Compact zinc finger base editors that edit mitochondrial or nuclear DNA in vitro and in vivo.
Willis JCW, Silva-Pinheiro P, Widdup L, Minczuk M, Liu DR. Willis JCW, et al. Nat Commun. 2022 Nov 23;13(1):7204. doi: 10.1038/s41467-022-34784-7. Nat Commun. 2022. PMID: 36418298 Free PMC article.
DddA-derived cytosine base editors (DdCBEs) use programmable DNA-binding TALE repeat arrays, rather than CRISPR proteins, a split double-stranded DNA cytidine deaminase (DddA), and a uracil glycosylase inhibitor to mediate CG-to-TA editing in nuclear and organelle DNA. Here we re …
DddA-derived cytosine base editors (DdCBEs) use programmable DNA-binding TALE repeat arrays, rather than CRISPR proteins, a split double-str …
226 results