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Cancer cells produce liver metastasis via gap formation in sinusoidal endothelial cells through proinflammatory paracrine mechanisms.
Huu Hoang T, Sato-Matsubara M, Yuasa H, Matsubara T, Thuy LTT, Ikenaga H, Phuong DM, Hanh NV, Hieu VN, Hoang DV, Hai H, Okina Y, Enomoto M, Tamori A, Daikoku A, Urushima H, Ikeda K, Dat NQ, Yasui Y, Shinkawa H, Kubo S, Yamagishi R, Ohtani N, Yoshizato K, Gracia-Sancho J, Kawada N. Huu Hoang T, et al. Among authors: okina y. Sci Adv. 2022 Sep 30;8(39):eabo5525. doi: 10.1126/sciadv.abo5525. Epub 2022 Sep 28. Sci Adv. 2022. PMID: 36170363 Free PMC article.
Nitric Oxide Derived from Cytoglobin-Deficient Hepatic Stellate Cells Causes Suppression of Cytochrome c Oxidase Activity in Hepatocytes.
Okina Y, Sato-Matsubara M, Kido Y, Urushima H, Daikoku A, Kadono C, Nakagama Y, Nitahara Y, Hoang TH, Thuy LTT, Matsubara T, Ohtani N, Ikeda K, Yoshizato K, Kawada N. Okina Y, et al. Antioxid Redox Signal. 2023 Mar;38(7-9):463-479. doi: 10.1089/ars.2021.0279. Antioxid Redox Signal. 2023. PMID: 36112670 Free PMC article.
TGF-β1-driven reduction of cytoglobin leads to oxidative DNA damage in stellate cells during non-alcoholic steatohepatitis.
Okina Y, Sato-Matsubara M, Matsubara T, Daikoku A, Longato L, Rombouts K, Thanh Thuy LT, Ichikawa H, Minamiyama Y, Kadota M, Fujii H, Enomoto M, Ikeda K, Yoshizato K, Pinzani M, Kawada N. Okina Y, et al. J Hepatol. 2020 Oct;73(4):882-895. doi: 10.1016/j.jhep.2020.03.051. Epub 2020 Apr 21. J Hepatol. 2020. PMID: 32330605 Free article.
Fibroblast growth factor 2 (FGF2) regulates cytoglobin expression and activation of human hepatic stellate cells via JNK signaling.
Sato-Matsubara M, Matsubara T, Daikoku A, Okina Y, Longato L, Rombouts K, Thuy LTT, Adachi J, Tomonaga T, Ikeda K, Yoshizato K, Pinzani M, Kawada N. Sato-Matsubara M, et al. Among authors: okina y. J Biol Chem. 2017 Nov 17;292(46):18961-18972. doi: 10.1074/jbc.M117.793794. Epub 2017 Sep 15. J Biol Chem. 2017. PMID: 28916723 Free PMC article.