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Showing results for tough chiyoda
Your search for Tough Chinoda retrieved no results
Validation of a New Methodology to Create Oral Drugs beyond the Rule of 5 for Intracellular Tough Targets.
Ohta A, Tanada M, Shinohara S, Morita Y, Nakano K, Yamagishi Y, Takano R, Kariyuki S, Iida T, Matsuo A, Ozeki K, Emura T, Sakurai Y, Takano K, Higashida A, Kojima M, Muraoka T, Takeyama R, Kato T, Kimura K, Ogawa K, Ohara K, Tanaka S, Kikuchi Y, Hisada N, Hayashi R, Nishimura Y, Nomura K, Tachibana T, Irie M, Kawada H, Torizawa T, Murao N, Kotake T, Tanaka M, Ishikawa S, Miyake T, Tamiya M, Arai M, Chiyoda A, Akai S, Sase H, Kuramoto S, Ito T, Shiraishi T, Kojima T, Iikura H. Ohta A, et al. J Am Chem Soc. 2023 Nov 8;145(44):24035-24051. doi: 10.1021/jacs.3c07145. Epub 2023 Oct 24. J Am Chem Soc. 2023. PMID: 37874670
In this study, we validated a new methodology to create oral drugs beyond the rule of 5 for intracellular tough targets by elucidating structural features and physicochemical properties for drug-like cyclic peptides and developing library technologies to afford highly N-al …
In this study, we validated a new methodology to create oral drugs beyond the rule of 5 for intracellular tough targets by elucidatin …
Development of Orally Bioavailable Peptides Targeting an Intracellular Protein: From a Hit to a Clinical KRAS Inhibitor.
Tanada M, Tamiya M, Matsuo A, Chiyoda A, Takano K, Ito T, Irie M, Kotake T, Takeyama R, Kawada H, Hayashi R, Ishikawa S, Nomura K, Furuichi N, Morita Y, Kage M, Hashimoto S, Nii K, Sase H, Ohara K, Ohta A, Kuramoto S, Nishimura Y, Iikura H, Shiraishi T. Tanada M, et al. J Am Chem Soc. 2023 Aug 2;145(30):16610-16620. doi: 10.1021/jacs.3c03886. Epub 2023 Jul 18. J Am Chem Soc. 2023. PMID: 37463267
Cyclic peptides as a therapeutic modality are attracting a lot of attention due to their potential for oral absorption and accessibility to intracellular tough targets. Here, starting with a drug-like hit discovered using an mRNA display library, we describe a chemical opt …
Cyclic peptides as a therapeutic modality are attracting a lot of attention due to their potential for oral absorption and accessibility to …
Skillful Control of Dispersion and 3D Network Structures: Advances in Functional Organic-Inorganic Nano-Hybrid Materials Prepared Using the Sol-Gel Method.
Ikake H, Hara S, Shimizu S. Ikake H, et al. Polymers (Basel). 2022 Aug 9;14(16):3247. doi: 10.3390/polym14163247. Polymers (Basel). 2022. PMID: 36015502 Free PMC article. Review.
Harmonization of both these factors has enabled the utilization of functional 3D network structures and nanodispersions in composite materials. Polymeric materials endow materials with flexibility, toughness, and shape-memory properties, whereas inorganic materials provide …
Harmonization of both these factors has enabled the utilization of functional 3D network structures and nanodispersions in composite materia …
Progress in thermomechanical control of steel plates and their commercialization.
Nishioka K, Ichikawa K. Nishioka K, et al. Sci Technol Adv Mater. 2012 Apr 3;13(2):023001. doi: 10.1088/1468-6996/13/2/023001. eCollection 2012 Apr. Sci Technol Adv Mater. 2012. PMID: 27877477 Free PMC article. Review.
The water-cooled thermomechanical control process (TMCP) is a technology for improving the strength and toughness of water-cooled steel plates, while allowing control of the microstructure, phase transformation and rolling. ...We provide some of the latest examples of appl …
The water-cooled thermomechanical control process (TMCP) is a technology for improving the strength and toughness of water-cooled ste …
Tailoring mechanical and in vitro biological properties of calcium‒silicate based bioceramic through iron doping in developing future material.
Myat-Htun M, Mohd Noor AF, Kawashita M, Baba Ismail YM. Myat-Htun M, et al. J Mech Behav Biomed Mater. 2022 Apr;128:105122. doi: 10.1016/j.jmbbm.2022.105122. Epub 2022 Feb 7. J Mech Behav Biomed Mater. 2022. PMID: 35168129
., diametral tensile strength, Vickers microhardness and fracture toughness) were observed for the doped ceramics at 1250 C, indicating that this newly developed formulation is temperature-dependent. ...
., diametral tensile strength, Vickers microhardness and fracture toughness) were observed for the doped ceramics at 1250 C, indicati …
Macroscopic Property Evaluation of Titania Nanocomposite Polymer Capable of Drawing Double-Network Macrostructure Using Photolithography.
Ikake H, Hara S, Kubodera M, Kato H, Fukasawa K, Takeoka Y, Ikehara T, Shimizu S. Ikake H, et al. ACS Macro Lett. 2023 Jul 18;12(7):943-948. doi: 10.1021/acsmacrolett.3c00230. Epub 2023 Jun 29. ACS Macro Lett. 2023. PMID: 37382535
Moreover, introducing microstructures using the photolithography technique improved the tensile strength and fracture energy by approximately 32 and 15 times, respectively, compared to the sample without the photoreaction. The improved toughness was achieved by the macrost …
Moreover, introducing microstructures using the photolithography technique improved the tensile strength and fracture energy by approximatel …
Highly Impact-Resistant Block Polymer-Based Thermoplastic Elastomers with an Ionically Functionalized Rubber Phase.
Kajita T, Noro A, Oda R, Hashimoto S. Kajita T, et al. ACS Omega. 2021 Dec 20;7(3):2821-2830. doi: 10.1021/acsomega.1c05609. eCollection 2022 Jan 25. ACS Omega. 2021. PMID: 35097278 Free PMC article.
By ionizing the rubber component in polystyrene-b-polyisoprene-b-polystyrene (SIS), we prepared several tens of grams of SIS-based elastomers with an ionically functionalized rubber phase and a sodium cation (i-SIS(Na)) or a bulky barium cation (i-SIS(Ba)). The i-SIS(Na) and i-SI …
By ionizing the rubber component in polystyrene-b-polyisoprene-b-polystyrene (SIS), we prepared several tens of grams of SIS-based elastomer …
Enhancement of the mechanical properties of organic-inorganic hybrid elastomers by introducing movable and reversible crosslinks.
Yamashita N, Yamaoka K, Ikura R, Yoshida D, Park J, Kato N, Kamei M, Ogura K, Igarashi M, Nakagawa H, Takashima Y. Yamashita N, et al. Soft Matter. 2023 Nov 29;19(46):9074-9081. doi: 10.1039/d3sm01101a. Soft Matter. 2023. PMID: 37987102
Introducing reversible crosslinks improved the Young's modulus and toughness values. The movable and reversible crosslinks between the organic and inorganic polymers contributed to the high elongation properties. ...
Introducing reversible crosslinks improved the Young's modulus and toughness values. The movable and reversible crosslinks between th …
Mechanically Reinforced Gelatin Hydrogels by Introducing Slidable Supramolecular Cross-Linkers.
Lee DH, Tamura A, Arisaka Y, Seo JH, Yui N. Lee DH, et al. Polymers (Basel). 2019 Nov 1;11(11):1787. doi: 10.3390/polym11111787. Polymers (Basel). 2019. PMID: 31683825 Free PMC article.
Tough mechanical properties are generally required for tissue substitutes used in regeneration of damaged tissue, as these substitutes must be able to withstand the external physical force caused by stretching. ...Indeed, the stretchability and toughness of gelatin …
Tough mechanical properties are generally required for tissue substitutes used in regeneration of damaged tissue, as these substitute …
Effect of loading conditions on the fracture toughness of zirconia.
Harada K, Shinya A, Yokoyama D, Shinya A. Harada K, et al. J Prosthodont Res. 2013 Apr;57(2):82-7. doi: 10.1016/j.jpor.2013.01.005. Epub 2013 Mar 14. J Prosthodont Res. 2013. PMID: 23498598 Free article.
Calculated Vickers hardness and fracture toughness values were analyzed with one-way analysis of variance and then multiple comparisons (Scheffe). ...Due to the hardness of zirconia and the light loads, fracture toughness values for 9.8, 49, and 98 N could not be ca …
Calculated Vickers hardness and fracture toughness values were analyzed with one-way analysis of variance and then multiple compariso …
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