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siRNA screening identifies METTL9 as a histidine Nπ-methyltransferase that targets the proinflammatory protein S100A9.
Daitoku H, Someya M, Kako K, Hayashi T, Tajima T, Haruki H, Sekiguchi N, Uetake T, Akimoto Y, Fukamizu A. Daitoku H, et al. J Biol Chem. 2021 Nov;297(5):101230. doi: 10.1016/j.jbc.2021.101230. Epub 2021 Sep 23. J Biol Chem. 2021. PMID: 34562450 Free PMC article.
However, the biological significance of protein histidine methylation remains largely unclear owing in part to the very limited knowledge about its contributing enzymes. Here, we identified mammalian seven-beta-strand methyltransferase METTL9 as a histidine Npi-methyltrans …
However, the biological significance of protein histidine methylation remains largely unclear owing in part to the very limited knowledge ab …