Abstract
By combining S1 nuclease with two strands of pseudo-complementary peptide nucleic acid (pcPNA), the whole human genome was selectively cut at targeted sites, and desired fragments were clipped from the genome.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Chromosomes / chemistry
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DNA / chemistry
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DNA, Single-Stranded / chemistry
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Fungal Proteins / chemistry*
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Genome, Human*
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Humans
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Molecular Sequence Data
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Peptide Nucleic Acids / chemistry*
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Single-Strand Specific DNA and RNA Endonucleases / chemistry*
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Telomere / chemistry
Substances
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DNA, Single-Stranded
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Fungal Proteins
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Peptide Nucleic Acids
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DNA
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Endonuclease S1, Aspergillus
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Single-Strand Specific DNA and RNA Endonucleases