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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1963 1
1965 1
1967 1
1974 1
1975 1
1976 2
1977 5
1979 2
1980 1
1981 4
1982 2
1983 6
1984 2
1985 1
1986 7
1988 1
1989 3
1990 6
1991 6
1992 7
1993 1
1994 9
1995 3
1996 3
1997 3
1998 2
1999 2
2000 8
2001 2
2002 4
2003 10
2004 6
2005 12
2006 6
2007 12
2008 10
2009 10
2010 14
2011 10
2012 21
2013 28
2014 46
2015 27
2016 41
2017 30
2018 27
2019 41
2020 58
2021 62
2022 62
2023 70
2024 28

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626 results

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Page 1
Evidence-Based Use of Levothyroxine/Liothyronine Combinations in Treating Hypothyroidism: A Consensus Document.
Jonklaas J, Bianco AC, Cappola AR, Celi FS, Fliers E, Heuer H, McAninch EA, Moeller LC, Nygaard B, Sawka AM, Watt T, Dayan CM. Jonklaas J, et al. Thyroid. 2021 Feb;31(2):156-182. doi: 10.1089/thy.2020.0720. Thyroid. 2021. PMID: 33276704 Free PMC article. Review.
Recent scientific developments may provide insight into this inconsistency and guide future studies. Methods: The American Thyroid Association (ATA), British Thyroid Association (BTA), and European Thyroid Association (ETA) held a joint conference on November 3, 2019 (live …
Recent scientific developments may provide insight into this inconsistency and guide future studies. Methods: The American Thyroid Associati …
Cellular functions of the protein kinase ATM and their relevance to human disease.
Lee JH, Paull TT. Lee JH, et al. Nat Rev Mol Cell Biol. 2021 Dec;22(12):796-814. doi: 10.1038/s41580-021-00394-2. Epub 2021 Aug 24. Nat Rev Mol Cell Biol. 2021. PMID: 34429537 Review.
In this Review, we discuss recent structural insights into ATM regulation, and possible aetiologies of A-T phenotypes, including reactive oxygen species, mitochondrial dysfunction, alterations in transcription, R-loop metabolism and alternative splicing, defects in cellula …
In this Review, we discuss recent structural insights into ATM regulation, and possible aetiologies of A-T phenotypes, including reactive ox …
Turning thermostability of Aspergillus terreus (R)-selective transaminase At-ATA by synthetic shuffling.
Fan F, Liu C, Cao J, Lyu C, Qiu S, Hu S, Sun T, Mei J, Wang H, Li Y, Zhao W, Mei L, Huang J. Fan F, et al. J Biotechnol. 2023 Feb 20;364:66-74. doi: 10.1016/j.jbiotec.2023.01.014. Epub 2023 Jan 25. J Biotechnol. 2023. PMID: 36708998
Here, synthetic shuffling technology was used to enhance stability of (R)-selective transaminase from Aspergillus terreus. The results showed that 30 out of 5000 mutants had improved thermostability by color-based screening method, among which mutants with residual enzyme …
Here, synthetic shuffling technology was used to enhance stability of (R)-selective transaminase from Aspergillus terreus. The result …
Expanding the Toolbox of R-Selective Amine Transaminases by Identification and Characterization of New Members.
Telzerow A, Paris J, Håkansson M, González-Sabín J, Ríos-Lombardía N, Gröger H, Morís F, Schürmann M, Schwab H, Steiner K. Telzerow A, et al. Chembiochem. 2021 Apr 6;22(7):1232-1242. doi: 10.1002/cbic.202000692. Epub 2020 Dec 28. Chembiochem. 2021. PMID: 33242357 Free PMC article.
We identified and characterized four new (R)-ATAs. The ATA from Exophiala sideris contains a motif characteristic for d-ATAs, which was previously believed to be a disqualifying factor for (R)-ATA activity. The crystal structure of the ATA from …
We identified and characterized four new (R)-ATAs. The ATA from Exophiala sideris contains a motif characteristic for d-ATAs, …
Creation of (R)-Amine Transaminase Activity within an alpha-Amino Acid Transaminase Scaffold.
Voss M, Xiang C, Esque J, Nobili A, Menke MJ, André I, Höhne M, Bornscheuer UT. Voss M, et al. ACS Chem Biol. 2020 Feb 21;15(2):416-424. doi: 10.1021/acschembio.9b00888. Epub 2020 Feb 11. ACS Chem Biol. 2020. PMID: 31990173 Free article.
Although many publications have dealt with enzyme discovery, protein engineering, and the application of (R)-selective amine transaminases [(R)-ATA] in biocatalysis, little is known about the actual in vivo role and how these enzymes have evolved from the ubi …
Although many publications have dealt with enzyme discovery, protein engineering, and the application of (R)-selective amine transami …
Shifting the pH Optima of (R)-Selective Transaminases by Protein Engineering.
Xiang C, Ao YF, Höhne M, Bornscheuer UT. Xiang C, et al. Int J Mol Sci. 2022 Dec 5;23(23):15347. doi: 10.3390/ijms232315347. Int J Mol Sci. 2022. PMID: 36499674 Free PMC article.
This resulted in the discovery of the variant E49Q of the ATA from Aspergillus fumigatus, for which the pH optimum was successfully shifted from pH 8.5 to 7.5 and this variant furthermore had a two times higher specific activity than the wild-type protein at pH 7.5. A poss …
This resulted in the discovery of the variant E49Q of the ATA from Aspergillus fumigatus, for which the pH optimum was successfully s …
M(r) 6,400 aurin tricarboxylic acid directly activates platelets.
Guo Z, Weinstein MJ, Phillips MD, Kroll MH. Guo Z, et al. Thromb Res. 1993 Jul 1;71(1):77-88. doi: 10.1016/0049-3848(93)90207-5. Thromb Res. 1993. PMID: 8367837
ATA fractions of M(r) > or = 2,500 are most effective at inhibiting vWF-mediated platelet aggregation, and ATA of M(r) = 2,500 also inhibits thrombin-induced platelet activation. Paradoxical results were observed in studies of ATA with M(r …
ATA fractions of M(r) > or = 2,500 are most effective at inhibiting vWF-mediated platelet aggregation, and ATA of M( …
Thyroid lobectomy for low-risk thyroid cancers.
Puttergill B, Khan S, Christakis I, Dumbill R, Mclaren A, Sadler G, Mihai R. Puttergill B, et al. Ann R Coll Surg Engl. 2022 Feb;104(2):113-116. doi: 10.1308/rcsann.2021.0058. Ann R Coll Surg Engl. 2022. PMID: 35100851 Free PMC article.
BACKGROUND: The 2016 American Thyroid Association (ATA) guidelines proposed thyroid lobectomy for low-risk differentiated thyroid cancer (DTC); however, this approach is yet to be widely adopted. ...Overall, 39% (n = 37) of patients underwent completion thyroidectomy accor …
BACKGROUND: The 2016 American Thyroid Association (ATA) guidelines proposed thyroid lobectomy for low-risk differentiated thyroid can …
Hyperoxic preconditioning in partial liver ischemia.
Margarido MR, Silveira MR, Vanni JC, Feres O, Castro-E-Silva O. Margarido MR, et al. Acta Cir Bras. 2014;29 Suppl 1:19-23. doi: 10.1590/s0102-86502014001300004. Acta Cir Bras. 2014. PMID: 25185051 Free article.
HBO I/R 2 ATA, 30 minutes of HBO (2 ATA) during the ischemia time. Pre HBO I/R 30', rats submitted to 30 minutes of HBO (2 ATA) immediately before the I/R time. Pre HBO I/R 90', rats submitted to 90 minutes of HBO (2 ATA) im …
HBO I/R 2 ATA, 30 minutes of HBO (2 ATA) during the ischemia time. Pre HBO I/R 30', rats submitted to 30 minutes …
Autologous dendritic cells loaded with antigens from self-renewing autologous tumor cells as patient-specific therapeutic cancer vaccines.
Dillman RO, Nistor GI, Keirstead HS. Dillman RO, et al. Hum Vaccin Immunother. 2023 Dec 31;19(1):2198467. doi: 10.1080/21645515.2023.2198467. Epub 2023 May 3. Hum Vaccin Immunother. 2023. PMID: 37133853 Free PMC article.
A promising personal immunotherapy is autologous dendritic cells (DC) loaded ex vivo with autologous tumor antigens (ATA) derived from self-renewing autologous cancer cells. DC-ATA are suspended in granulocyte-macrophage colony stimulating factor at the time of each …
A promising personal immunotherapy is autologous dendritic cells (DC) loaded ex vivo with autologous tumor antigens (ATA) derived fro …
626 results