TopBP1 utilises a bipartite GINS binding mode to support genome replication.
Day M, Tetik B, Parlak M, Almeida-Hernández Y, Räschle M, Kaschani F, Siegert H, Marko A, Sanchez-Garcia E, Kaiser M, Barker IA, Pearl LH, Oliver AW, Boos D.
Day M, et al.
Nat Commun. 2024 Feb 27;15(1):1797. doi: 10.1038/s41467-024-45946-0.
Nat Commun. 2024.
PMID: 38413589
Free PMC article.
Our biochemical and structural studies demonstrate that the helicase activator GINS interacts with TopBP1 through two separate binding surfaces, the first involving a stretch of highly conserved amino acids in the TopBP1-GINI region, the second a surface on TopBP1-BRCT4. The two …
Our biochemical and structural studies demonstrate that the helicase activator GINS interacts with TopBP1 through two separate binding surfa …