Cardiac Overexpression of PDE4B Blunts β-Adrenergic Response and Maladaptive Remodeling in Heart Failure.
Karam S, Margaria JP, Bourcier A, Mika D, Varin A, Bedioune I, Lindner M, Bouadjel K, Dessillons M, Gaudin F, Lefebvre F, Mateo P, Lechène P, Gomez S, Domergue V, Robert P, Coquard C, Algalarrondo V, Samuel JL, Michel JB, Charpentier F, Ghigo A, Hirsch E, Fischmeister R, Leroy J, Vandecasteele G.
Karam S, et al.
Circulation. 2020 Jul 14;142(2):161-174. doi: 10.1161/CIRCULATIONAHA.119.042573. Epub 2020 Apr 8.
Circulation. 2020.
PMID: 32264695
RESULTS: PDE4B protein was decreased in human failing hearts. The first PDE4B-transgenic mouse line (TG15) had a 15-fold increase in cardiac cAMP-PDE activity and a 30% decrease in cAMP content and fractional shortening associated with a mild cardiac hypertrophy that resor …
RESULTS: PDE4B protein was decreased in human failing hearts. The first PDE4B-transgenic mouse line (TG15) had a 15-fold increase in …