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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1954 1
1972 1
1975 9
1976 12
1977 15
1978 17
1979 6
1980 26
1981 25
1982 26
1983 41
1984 39
1985 34
1986 40
1987 45
1988 81
1989 89
1990 114
1991 167
1992 188
1993 206
1994 250
1995 291
1996 314
1997 340
1998 322
1999 396
2000 397
2001 472
2002 495
2003 604
2004 678
2005 841
2006 926
2007 1046
2008 1135
2009 1365
2010 1463
2011 1638
2012 1786
2013 1950
2014 2264
2015 2567
2016 1710
2017 1295
2018 1822
2019 1988
2020 2226
2021 2209
2022 2069
2023 1820
2024 421

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34,143 results

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Page 1
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14.
Lee RC, Feinbaum RL, Ambros V. Lee RC, et al. Cell. 1993 Dec 3;75(5):843-54. doi: 10.1016/0092-8674(93)90529-y. Cell. 1993. PMID: 8252621
lin-4 is essential for the normal temporal control of diverse postembryonic developmental events in C. elegans. lin-4 acts by negatively regulating the level of LIN-14 protein, creating a temporal decrease in LIN-14 protein starting in the first …
lin-4 is essential for the normal temporal control of diverse postembryonic developmental events in C. elegans. lin-4 a …
CD28-CAR-T cell activation through FYN kinase signaling rather than LCK enhances therapeutic performance.
Wu L, Brzostek J, Sakthi Vale PD, Wei Q, Koh CKT, Ong JXH, Wu LZ, Tan JC, Chua YL, Yap J, Song Y, Tan VJY, Tan TYY, Lai J, MacAry PA, Gascoigne NRJ. Wu L, et al. Cell Rep Med. 2023 Feb 21;4(2):100917. doi: 10.1016/j.xcrm.2023.100917. Epub 2023 Jan 24. Cell Rep Med. 2023. PMID: 36696897 Free PMC article.
Signal transduction induced by chimeric antigen receptors (CARs) is generally believed to rely on the activity of the SRC family kinase (SFK) LCK, as is the case with T cell receptor (TCR) signaling. Here, we show that CAR signaling occurs in the absence of LCK. This LCK-i …
Signal transduction induced by chimeric antigen receptors (CARs) is generally believed to rely on the activity of the SRC family kinase (SFK …
LIN-12/Notch signaling in C. elegans.
Greenwald I. Greenwald I. WormBook. 2005 Aug 8:1-16. doi: 10.1895/wormbook.1.10.1. WormBook. 2005. PMID: 18050403 Free PMC article. Review.
Studies in C. elegans have been instrumental in defining the basic features of the LIN-12/Notch pathway, the role of LIN-12/Notch proteins as receptors for intercellular signals, the mechanism of signal transduction, and the regulation of LIN-12/Notch …
Studies in C. elegans have been instrumental in defining the basic features of the LIN-12/Notch pathway, the role of LIN …
Vulval development.
Sternberg PW. Sternberg PW. WormBook. 2005 Jun 25:1-28. doi: 10.1895/wormbook.1.6.1. WormBook. 2005. PMID: 18050418 Free PMC article. Review.
C. elegans vulval development is an intensively studied example of animal organogenesis. ...The reversed polarity of the posterior secondary precursor cell lineage requires WNT signaling mediated by both Frizzled class and Ryk class WNT-receptors LIN-17 and LIN …
C. elegans vulval development is an intensively studied example of animal organogenesis. ...The reversed polarity of the posterior se …
Enrichment of c-kit+ Lin- haemopoietic progenitor cells that commit themselves to extrathymic T cells in in vitro culture of appendix mononuclear cells.
Koya T, Honda S, Narita J, Watanabe H, Arakawa M, Abo T. Koya T, et al. Immunology. 1999 Mar;96(3):447-56. doi: 10.1046/j.1365-2567.1999.00686.x. Immunology. 1999. PMID: 10233727 Free PMC article.
When appendix mononuclear cells (MNC) were cultured in the presence of stem cell factor, interleukin-3, interleukin-6 and erythropoietin on a methylcellulose culture plate, the population of c-kitdull Lin- and that of c-kithi Lin- cells expanded. Morph …
When appendix mononuclear cells (MNC) were cultured in the presence of stem cell factor, interleukin-3, interleukin-6 and erythropoietin on …
CD4+ T-cell anergy induced by lin- CD117(c-kit)+ stem cell-derived immature dendritic cells loaded with nuclear antigen derived from Trypanosoma equiperdum.
Xia Y, Zhang Y, Jiang S, Cheng H. Xia Y, et al. Autoimmunity. 2010 Dec;43(8):664-71. doi: 10.3109/08916931003674691. Epub 2010 Apr 7. Autoimmunity. 2010. PMID: 20370574
Dendritic cells (DCs) are professional antigen-presenting cells, which have the extraordinary capacity to initiate naive T-cell-mediated primary immune responses. To investigate the role of DCs in the induction of antigen-specific tolerance, the immature DCs (imDCs) and ma …
Dendritic cells (DCs) are professional antigen-presenting cells, which have the extraordinary capacity to initiate naive T-cell-media …
LiN(SiMe(3))(2)/KO(t)Bu-Promoted Synthesis of Isoquinolone Derivatives from 2-Methylaryl Aldehydes and Nitriles.
Ma P, Wang Y, Wang J, Ma N. Ma P, et al. J Org Chem. 2023 Jun 2;88(11):7425-7430. doi: 10.1021/acs.joc.3c00698. Epub 2023 May 17. J Org Chem. 2023. PMID: 37195013
A convenient method is proposed for the synthesis of isoquinolone derivatives from 2-methylaryl aldehydes and nitriles through LiN(SiMe(3))(2)/KO(t)Bu-promoted formal [4 + 2] cycloaddition reaction, featuring high atomic economy, good functional group tolerance, and …
A convenient method is proposed for the synthesis of isoquinolone derivatives from 2-methylaryl aldehydes and nitriles through LiN(Si …
Life Cycle of Cryptococcus neoformans.
Zhao Y, Lin J, Fan Y, Lin X. Zhao Y, et al. Annu Rev Microbiol. 2019 Sep 8;73:17-42. doi: 10.1146/annurev-micro-020518-120210. Epub 2019 May 13. Annu Rev Microbiol. 2019. PMID: 31082304 Review.
Advances in genomics, genetics, and cellular and molecular biology of C. neoformans have dramatically improved our understanding of this important pathogen, rendering it a model organism to study eukaryotic biology and microbial pathogenesis. In light of recent progress, w …
Advances in genomics, genetics, and cellular and molecular biology of C. neoformans have dramatically improved our understanding of t …
Intestinal Lin- c-Kit+ NKp46- CD4- population strongly produces IL-22 upon IL-1beta stimulation.
Lee Y, Kumagai Y, Jang MS, Kim JH, Yang BG, Lee EJ, Kim YM, Akira S, Jang MH. Lee Y, et al. J Immunol. 2013 May 15;190(10):5296-305. doi: 10.4049/jimmunol.1201452. Epub 2013 Apr 15. J Immunol. 2013. PMID: 23589614
In a global gene-expression analysis comparing small intestinal ILCs (Lin(-)c-Kit(+)Sca-1(-) cells) with non-ILCs (Lin(-)c-Kit(-)Sca-1(-) cells), we found that Lin(-)c-Kit(+)Sca-1(-) cells highly expressed the mRNAs for Il22, antimicrobia …
In a global gene-expression analysis comparing small intestinal ILCs (Lin(-)c-Kit(+)Sca-1(-) cells) with non-ILCs (Lin( …
34,143 results
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