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The interferon-gamma-induced GTPase, mGBP-2, inhibits tumor necrosis factor alpha (TNF-alpha) induction of matrix metalloproteinase-9 (MMP-9) by inhibiting NF-kappaB and Rac protein.
Balasubramanian S, Fan M, Messmer-Blust AF, Yang CH, Trendel JA, Jeyaratnam JA, Pfeffer LM, Vestal DJ. Balasubramanian S, et al. Among authors: messmer blust af. J Biol Chem. 2011 Jun 3;286(22):20054-64. doi: 10.1074/jbc.M111.249326. Epub 2011 Apr 18. J Biol Chem. 2011. PMID: 21502320 Free PMC article.
The interferon-gamma-induced murine guanylate-binding protein-2 inhibits rac activation during cell spreading on fibronectin and after platelet-derived growth factor treatment: role for phosphatidylinositol 3-kinase.
Messmer-Blust AF, Balasubramanian S, Gorbacheva VY, Jeyaratnam JA, Vestal DJ. Messmer-Blust AF, et al. Mol Biol Cell. 2010 Jul 15;21(14):2514-28. doi: 10.1091/mbc.e09-04-0344. Epub 2010 May 26. Mol Biol Cell. 2010. PMID: 20505078 Free PMC article.